Loss of Sparc in p 53‐null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival

Both the induction of SPARC expression and the loss of the p53 tumor suppressor gene are changes that occur early in glioma development. Both SPARC and p53 regulate glioma cell survival by inverse effects on apoptotic signaling. Therefore, during glioma formation, the upregulation of SPARC may coope...

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Detalles Bibliográficos
Autores principales: Thomas, Stacey L., Schultz, Chad R., Mouzon, Ezekiell, Golembieski, William A., Naili, Reima El, Radakrishnan, Archanna, Lemke, Nancy, Poisson, Laila M., Gutiérrez, Jorge A., Cottingham, Sandra, Rempel, Sandra A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520390/
https://www.ncbi.nlm.nih.gov/pubmed/24862407
http://dx.doi.org/10.1111/bpa.12161

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