BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma

Type II germ cell cancers (GCC) can be subdivided into seminomas and non-seminomas. Seminomas are similar to carcinoma in situ (CIS) cells, the common precursor of type II GCCs, with regard to epigenetics and expression, while embryonal carcinomas (EC) are totipotent and differentiate into teratomas...

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Detalles Bibliográficos
Autores principales: Nettersheim, Daniel, Jostes, Sina, Sharma, Rakesh, Schneider, Simon, Hofmann, Andrea, Ferreira, Humberto J., Hoffmann, Per, Kristiansen, Glen, Esteller, Manel B., Schorle, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520454/
https://www.ncbi.nlm.nih.gov/pubmed/26226633
http://dx.doi.org/10.1371/journal.pgen.1005415

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