GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway

Previously we demonstrated that human glioblastoma cell lines induce apoptosis in peripheral blood T cells through partial involvement of secreted gangliosides. Here we show that GBM-derived gangliosides induce apoptosis through involvement of the TNF receptor and activation of the caspase cascade....

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Detalles Bibliográficos
Autores principales: Mahata, Barun, Biswas, Soumika, Rayman, Patricia, Chahlavi, Ali, Ko, Jennifer, Bhattacharjee, Ashish, Li, Yu-Teh, Li, Yuntao, Das, Tanya, Sa, Gaurisankar, Raychaudhuri, Baisakhi, Vogelbaum, Michael A., Tannenbaum, Charles, Finke, James H., Biswas, Kaushik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520498/
https://www.ncbi.nlm.nih.gov/pubmed/26226135
http://dx.doi.org/10.1371/journal.pone.0134425

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