Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents

Activating mutations in the Kir6.2 (KCNJ11) subunit of the ATP-sensitive potassium channel cause neonatal diabetes (ND). Patients with severe mutations also suffer from neurological complications. Glibenclamide blocks the open K(ATP) channels and is the treatment of choice for ND. However, although...

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Detalles Bibliográficos
Autores principales: Lahmann, Carolina, Kramer, Holger B., Ashcroft, Frances M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520580/
https://www.ncbi.nlm.nih.gov/pubmed/26225433
http://dx.doi.org/10.1371/journal.pone.0134476

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