Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model

Monitoring the DNA-Damage Response (DDR) activated pathway in multicellular tumor spheroid models is an important challenge as these 3D models have demonstrated their major relevance in pharmacological evaluation. Herein we present DDR-Act-FP, a fluorescent biosensor that allows detection of DDR act...

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Detalles Bibliográficos
Autores principales: Mondesert, Odile, Frongia, Céline, Clayton, Olivia, Boizeau, Marie-Laure, Lobjois, Valérie, Ducommun, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520595/
https://www.ncbi.nlm.nih.gov/pubmed/26225756
http://dx.doi.org/10.1371/journal.pone.0134411

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