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Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents

The Fanconi anemia (FA) pathway plays a key role in interstrand crosslink (ICL) repair and maintenance of the genomic stability, while inhibition of this pathway may sensitize cancer cells to DNA ICL agents and ionizing radiation (IR). The active FA core complex acts as an E3 ligase to monoubiquitin...

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Detalles Bibliográficos
Autores principales:	Wang, Gui-Zhen, Liu, Yong-Qiang, Cheng, Xin, Zhou, Guang-Biao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520643/ https://www.ncbi.nlm.nih.gov/pubmed/25891850 http://dx.doi.org/10.1111/cas.12679

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