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Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-Ras(G12V)-induced lung cancer by induction of telomeric DNA damage
Telomeres are considered anti-cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer-prone mouse models, however, only decreased tumor growth after several mouse generations when telomeres reach a critically short length, and th...
Autores principales: | García-Beccaria, María, Martínez, Paula, Méndez-Pertuz, Marinela, Martínez, Sonia, Blanco-Aparicio, Carmen, Cañamero, Marta, Mulero, Francisca, Ambrogio, Chiara, Flores, Juana M, Megias, Diego, Barbacid, Mariano, Pastor, Joaquín, Blasco, Maria A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520658/ https://www.ncbi.nlm.nih.gov/pubmed/25971796 http://dx.doi.org/10.15252/emmm.201404497 |
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