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Model-Based Individualized Treatment of Chemotherapeutics: Bayesian Population Modeling and Dose Optimization

6-Mercaptopurine (6-MP) is one of the key drugs in the treatment of many pediatric cancers, auto immune diseases and inflammatory bowel disease. 6-MP is a prodrug, converted to an active metabolite 6-thioguanine nucleotide (6-TGN) through enzymatic reaction involving thiopurine methyltransferase (TP...

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Detalles Bibliográficos
Autores principales:	Jayachandran, Devaraj, Laínez-Aguirre, José, Rundell, Ann, Vik, Terry, Hannemann, Robert, Reklaitis, Gintaras, Ramkrishna, Doraiswami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520687/ https://www.ncbi.nlm.nih.gov/pubmed/26226448 http://dx.doi.org/10.1371/journal.pone.0133244

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