An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

The persistence of latently infected cells in patients under combinatory antiretroviral therapy (cART) is a major hurdle to HIV-1 eradication. Strategies to purge these reservoirs are needed and activation of viral gene expression in latently infected cells is one promising strategy. Bromodomain and...

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Detalles Bibliográficos
Autores principales: Darcis, Gilles, Kula, Anna, Bouchat, Sophie, Fujinaga, Koh, Corazza, Francis, Ait-Ammar, Amina, Delacourt, Nadège, Melard, Adeline, Kabeya, Kabamba, Vanhulle, Caroline, Van Driessche, Benoit, Gatot, Jean-Stéphane, Cherrier, Thomas, Pianowski, Luiz F., Gama, Lucio, Schwartz, Christian, Vila, Jorge, Burny, Arsène, Clumeck, Nathan, Moutschen, Michel, De Wit, Stéphane, Peterlin, B. Matija, Rouzioux, Christine, Rohr, Olivier, Van Lint, Carine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520688/
https://www.ncbi.nlm.nih.gov/pubmed/26225566
http://dx.doi.org/10.1371/journal.ppat.1005063

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