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Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients

The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6...

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Autores principales: Ban, Ga-Young, Ye, Young-Min, Lee, Yunhwan, Kim, Jeong-Eun, Nam, Young-Hee, Lee, Soo-Keol, Kim, Joo-Hee, Jung, Ki-Suck, Kim, Sang-Ha, Park, Hae-Sim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520933/
https://www.ncbi.nlm.nih.gov/pubmed/26240480
http://dx.doi.org/10.3346/jkms.2015.30.8.1042
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author Ban, Ga-Young
Ye, Young-Min
Lee, Yunhwan
Kim, Jeong-Eun
Nam, Young-Hee
Lee, Soo-Keol
Kim, Joo-Hee
Jung, Ki-Suck
Kim, Sang-Ha
Park, Hae-Sim
author_facet Ban, Ga-Young
Ye, Young-Min
Lee, Yunhwan
Kim, Jeong-Eun
Nam, Young-Hee
Lee, Soo-Keol
Kim, Joo-Hee
Jung, Ki-Suck
Kim, Sang-Ha
Park, Hae-Sim
author_sort Ban, Ga-Young
collection PubMed
description The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwise pharmacologic treatment based on the Global Initiative for Asthma (GINA) guideline. A total of 296 asthmatic patients aged ≥ 60 yr were recruited from 5 university centers in Korea. The improved-asthma control group was defined as the group of patients who maintained well-controlled or improved disease and the not-improved asthma control group was defined as the remaining patients. Fewer number of medications for comorbidities (2.8 ± 3.3 in the improved vs. 4.5 ± 4.4 in the control) and higher physical functioning (PF) scale (89.8 ± 14.2 in the improved vs. 82.0 ± 16.4 in the control) were significant predictors in the improved-asthma control group (OR = 0.863, P = 0.004 and OR = 1.028, P = 0.018, respectively). An asthma control test (ACT) score of ≤ 19 at baseline was a significant predictor of asthma exacerbation (OR = 3.938, P = 0.048). Asthma duration (F = 5.656, P = 0.018), ACT score (F = 12.237, P = 0.001) at baseline, and the presence of asthma exacerbation (F = 5.565, P = 0.019) were significant determinants of changes in A-QOL. The number of medications for comorbidities and performance status determined by the PF scale may be important parameters for assessing asthma control in elderly asthmatic patients. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-45209332015-08-03 Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients Ban, Ga-Young Ye, Young-Min Lee, Yunhwan Kim, Jeong-Eun Nam, Young-Hee Lee, Soo-Keol Kim, Joo-Hee Jung, Ki-Suck Kim, Sang-Ha Park, Hae-Sim J Korean Med Sci Original Article The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwise pharmacologic treatment based on the Global Initiative for Asthma (GINA) guideline. A total of 296 asthmatic patients aged ≥ 60 yr were recruited from 5 university centers in Korea. The improved-asthma control group was defined as the group of patients who maintained well-controlled or improved disease and the not-improved asthma control group was defined as the remaining patients. Fewer number of medications for comorbidities (2.8 ± 3.3 in the improved vs. 4.5 ± 4.4 in the control) and higher physical functioning (PF) scale (89.8 ± 14.2 in the improved vs. 82.0 ± 16.4 in the control) were significant predictors in the improved-asthma control group (OR = 0.863, P = 0.004 and OR = 1.028, P = 0.018, respectively). An asthma control test (ACT) score of ≤ 19 at baseline was a significant predictor of asthma exacerbation (OR = 3.938, P = 0.048). Asthma duration (F = 5.656, P = 0.018), ACT score (F = 12.237, P = 0.001) at baseline, and the presence of asthma exacerbation (F = 5.565, P = 0.019) were significant determinants of changes in A-QOL. The number of medications for comorbidities and performance status determined by the PF scale may be important parameters for assessing asthma control in elderly asthmatic patients. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2015-08 2015-07-15 /pmc/articles/PMC4520933/ /pubmed/26240480 http://dx.doi.org/10.3346/jkms.2015.30.8.1042 Text en © 2015 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ban, Ga-Young
Ye, Young-Min
Lee, Yunhwan
Kim, Jeong-Eun
Nam, Young-Hee
Lee, Soo-Keol
Kim, Joo-Hee
Jung, Ki-Suck
Kim, Sang-Ha
Park, Hae-Sim
Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients
title Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients
title_full Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients
title_fullStr Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients
title_full_unstemmed Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients
title_short Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients
title_sort predictors of asthma control by stepwise treatment in elderly asthmatic patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520933/
https://www.ncbi.nlm.nih.gov/pubmed/26240480
http://dx.doi.org/10.3346/jkms.2015.30.8.1042
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