Cargando…
Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients
The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520933/ https://www.ncbi.nlm.nih.gov/pubmed/26240480 http://dx.doi.org/10.3346/jkms.2015.30.8.1042 |
_version_ | 1782383732371488768 |
---|---|
author | Ban, Ga-Young Ye, Young-Min Lee, Yunhwan Kim, Jeong-Eun Nam, Young-Hee Lee, Soo-Keol Kim, Joo-Hee Jung, Ki-Suck Kim, Sang-Ha Park, Hae-Sim |
author_facet | Ban, Ga-Young Ye, Young-Min Lee, Yunhwan Kim, Jeong-Eun Nam, Young-Hee Lee, Soo-Keol Kim, Joo-Hee Jung, Ki-Suck Kim, Sang-Ha Park, Hae-Sim |
author_sort | Ban, Ga-Young |
collection | PubMed |
description | The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwise pharmacologic treatment based on the Global Initiative for Asthma (GINA) guideline. A total of 296 asthmatic patients aged ≥ 60 yr were recruited from 5 university centers in Korea. The improved-asthma control group was defined as the group of patients who maintained well-controlled or improved disease and the not-improved asthma control group was defined as the remaining patients. Fewer number of medications for comorbidities (2.8 ± 3.3 in the improved vs. 4.5 ± 4.4 in the control) and higher physical functioning (PF) scale (89.8 ± 14.2 in the improved vs. 82.0 ± 16.4 in the control) were significant predictors in the improved-asthma control group (OR = 0.863, P = 0.004 and OR = 1.028, P = 0.018, respectively). An asthma control test (ACT) score of ≤ 19 at baseline was a significant predictor of asthma exacerbation (OR = 3.938, P = 0.048). Asthma duration (F = 5.656, P = 0.018), ACT score (F = 12.237, P = 0.001) at baseline, and the presence of asthma exacerbation (F = 5.565, P = 0.019) were significant determinants of changes in A-QOL. The number of medications for comorbidities and performance status determined by the PF scale may be important parameters for assessing asthma control in elderly asthmatic patients. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-4520933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-45209332015-08-03 Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients Ban, Ga-Young Ye, Young-Min Lee, Yunhwan Kim, Jeong-Eun Nam, Young-Hee Lee, Soo-Keol Kim, Joo-Hee Jung, Ki-Suck Kim, Sang-Ha Park, Hae-Sim J Korean Med Sci Original Article The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwise pharmacologic treatment based on the Global Initiative for Asthma (GINA) guideline. A total of 296 asthmatic patients aged ≥ 60 yr were recruited from 5 university centers in Korea. The improved-asthma control group was defined as the group of patients who maintained well-controlled or improved disease and the not-improved asthma control group was defined as the remaining patients. Fewer number of medications for comorbidities (2.8 ± 3.3 in the improved vs. 4.5 ± 4.4 in the control) and higher physical functioning (PF) scale (89.8 ± 14.2 in the improved vs. 82.0 ± 16.4 in the control) were significant predictors in the improved-asthma control group (OR = 0.863, P = 0.004 and OR = 1.028, P = 0.018, respectively). An asthma control test (ACT) score of ≤ 19 at baseline was a significant predictor of asthma exacerbation (OR = 3.938, P = 0.048). Asthma duration (F = 5.656, P = 0.018), ACT score (F = 12.237, P = 0.001) at baseline, and the presence of asthma exacerbation (F = 5.565, P = 0.019) were significant determinants of changes in A-QOL. The number of medications for comorbidities and performance status determined by the PF scale may be important parameters for assessing asthma control in elderly asthmatic patients. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2015-08 2015-07-15 /pmc/articles/PMC4520933/ /pubmed/26240480 http://dx.doi.org/10.3346/jkms.2015.30.8.1042 Text en © 2015 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ban, Ga-Young Ye, Young-Min Lee, Yunhwan Kim, Jeong-Eun Nam, Young-Hee Lee, Soo-Keol Kim, Joo-Hee Jung, Ki-Suck Kim, Sang-Ha Park, Hae-Sim Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients |
title | Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients |
title_full | Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients |
title_fullStr | Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients |
title_full_unstemmed | Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients |
title_short | Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients |
title_sort | predictors of asthma control by stepwise treatment in elderly asthmatic patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520933/ https://www.ncbi.nlm.nih.gov/pubmed/26240480 http://dx.doi.org/10.3346/jkms.2015.30.8.1042 |
work_keys_str_mv | AT bangayoung predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients AT yeyoungmin predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients AT leeyunhwan predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients AT kimjeongeun predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients AT namyounghee predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients AT leesookeol predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients AT kimjoohee predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients AT jungkisuck predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients AT kimsangha predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients AT parkhaesim predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients AT predictorsofasthmacontrolbystepwisetreatmentinelderlyasthmaticpatients |