Cargando…
In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry
The possibility of directly converting non-neuronal cells into neurons in situ in the brain would open therapeutic avenues aimed at repairing the brain after injury or degenerative disease. We have developed an adeno-associated virus (AAV)-based reporter system that allows selective GFP labeling of...
Autores principales: | Torper, Olof, Ottosson, Daniella Rylander, Pereira, Maria, Lau, Shong, Cardoso, Tiago, Grealish, Shane, Parmar, Malin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521079/ https://www.ncbi.nlm.nih.gov/pubmed/26166567 http://dx.doi.org/10.1016/j.celrep.2015.06.040 |
Ejemplares similares
-
Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons
por: Pereira, Maria, et al.
Publicado: (2017) -
Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain
por: Pereira, Maria, et al.
Publicado: (2014) -
Striatal Plasticity in L-DOPA- and Graft-Induced Dyskinesia; The Common Link?
por: Rylander Ottosson, Daniella, et al.
Publicado: (2016) -
Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson’s Disease
por: Kirkeby, Agnete, et al.
Publicado: (2017) -
hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease
por: Adler, Andrew F., et al.
Publicado: (2019)