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Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C

Type I interferons (IFN-I) are expressed in the brain during many inflammatory and neurodegenerative conditions and have multiple effects on CNS function. IFN-I is readily induced in the brain by systemic administration of the viral mimetic, poly I:C (synthetic double-stranded RNA). We hypothesised...

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Detalles Bibliográficos
Autores principales:	Murray, Carol, Griffin, Éadaoin W., O’Loughlin, Elaine, Lyons, Aoife, Sherwin, Eoin, Ahmed, Suaad, Stevenson, Nigel J, Harkin, Andrew, Cunningham, Colm
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521083/ https://www.ncbi.nlm.nih.gov/pubmed/25900439 http://dx.doi.org/10.1016/j.bbi.2015.04.009

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