Cargando…

Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study

Background: Prenatal environmental factors such as maternal adiposity may influence the risk of offspring autism spectrum disorders (ASD), though current evidence is inconsistent. The objective of this study was to assess the relationship of parental BMI and gestational weight gain (GWG) with risk o...

Descripción completa

Detalles Bibliográficos
Autores principales: Gardner, Renee M, Lee, Brian K, Magnusson, Cecilia, Rai, Dheeraj, Frisell, Thomas, Karlsson, Håkan, Idring, Selma, Dalman, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521130/
https://www.ncbi.nlm.nih.gov/pubmed/26045508
http://dx.doi.org/10.1093/ije/dyv081
_version_ 1782383759407972352
author Gardner, Renee M
Lee, Brian K
Magnusson, Cecilia
Rai, Dheeraj
Frisell, Thomas
Karlsson, Håkan
Idring, Selma
Dalman, Christina
author_facet Gardner, Renee M
Lee, Brian K
Magnusson, Cecilia
Rai, Dheeraj
Frisell, Thomas
Karlsson, Håkan
Idring, Selma
Dalman, Christina
author_sort Gardner, Renee M
collection PubMed
description Background: Prenatal environmental factors such as maternal adiposity may influence the risk of offspring autism spectrum disorders (ASD), though current evidence is inconsistent. The objective of this study was to assess the relationship of parental BMI and gestational weight gain (GWG) with risk of offspring ASD in a population-based cohort study using family-based study designs. Methods: The cohort was based in Stockholm County, Sweden, including 333 057 individuals born 1984–2007, of whom 6420 were diagnosed with an ASD. We evaluated maternal body mass index (BMI) at first antenatal visit, GWG and paternal BMI at the time of conscription into the Swedish military as exposures using general estimating equation (GEE) models with logit link. Results: At the population level, maternal overweight/obesity was associated with increased risk of offspring ASD [odds ratio (OR)(25 ≤ BMI < 30) 1.31, 95% confidence interval = 1.21–1.41; OR(BMI ≥ 30) 1.94, 1.72–2.17], as was paternal underweight (OR(BMI < 18.5), 1.19, 1.06–1.33) and obesity (OR(BMI ≥ 30) 1.47, 1.12–1.92) in mutually adjusted models. However, in matched sibling analyses, the relationship between elevated maternal BMI and ASD risk was not apparent. GWG had a U-shaped association with offspring ASD at the population level (OR(insufficient) 1.22, 1.07–1.40; OR(excessive) 1.23, 1.08–1.40). Matched sibling analyses were suggestive of elevated risk with excessive GWG (OR(insufficient) 1.12, 0.68–1.84; OR(excessive) 1.48, 0.93–2.38). Conclusions: Whereas population-level results suggested that maternal BMI was associated with ASD, sibling analyses and paternal BMI analyses indicate that maternal BMI may also be a proxy marker for other familial risk factors. Evidence is stronger for a direct link between GWG and ASD risk.
format Online
Article
Text
id pubmed-4521130
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-45211302015-08-05 Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study Gardner, Renee M Lee, Brian K Magnusson, Cecilia Rai, Dheeraj Frisell, Thomas Karlsson, Håkan Idring, Selma Dalman, Christina Int J Epidemiol Early Life Exposures Background: Prenatal environmental factors such as maternal adiposity may influence the risk of offspring autism spectrum disorders (ASD), though current evidence is inconsistent. The objective of this study was to assess the relationship of parental BMI and gestational weight gain (GWG) with risk of offspring ASD in a population-based cohort study using family-based study designs. Methods: The cohort was based in Stockholm County, Sweden, including 333 057 individuals born 1984–2007, of whom 6420 were diagnosed with an ASD. We evaluated maternal body mass index (BMI) at first antenatal visit, GWG and paternal BMI at the time of conscription into the Swedish military as exposures using general estimating equation (GEE) models with logit link. Results: At the population level, maternal overweight/obesity was associated with increased risk of offspring ASD [odds ratio (OR)(25 ≤ BMI < 30) 1.31, 95% confidence interval = 1.21–1.41; OR(BMI ≥ 30) 1.94, 1.72–2.17], as was paternal underweight (OR(BMI < 18.5), 1.19, 1.06–1.33) and obesity (OR(BMI ≥ 30) 1.47, 1.12–1.92) in mutually adjusted models. However, in matched sibling analyses, the relationship between elevated maternal BMI and ASD risk was not apparent. GWG had a U-shaped association with offspring ASD at the population level (OR(insufficient) 1.22, 1.07–1.40; OR(excessive) 1.23, 1.08–1.40). Matched sibling analyses were suggestive of elevated risk with excessive GWG (OR(insufficient) 1.12, 0.68–1.84; OR(excessive) 1.48, 0.93–2.38). Conclusions: Whereas population-level results suggested that maternal BMI was associated with ASD, sibling analyses and paternal BMI analyses indicate that maternal BMI may also be a proxy marker for other familial risk factors. Evidence is stronger for a direct link between GWG and ASD risk. Oxford University Press 2015-06 2015-06-04 /pmc/articles/PMC4521130/ /pubmed/26045508 http://dx.doi.org/10.1093/ije/dyv081 Text en © The Author 2015. Published by Oxford University Press on behalf of the International Epidemiological Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Early Life Exposures
Gardner, Renee M
Lee, Brian K
Magnusson, Cecilia
Rai, Dheeraj
Frisell, Thomas
Karlsson, Håkan
Idring, Selma
Dalman, Christina
Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study
title Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study
title_full Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study
title_fullStr Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study
title_full_unstemmed Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study
title_short Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study
title_sort maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: results from a swedish total population and discordant sibling study
topic Early Life Exposures
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521130/
https://www.ncbi.nlm.nih.gov/pubmed/26045508
http://dx.doi.org/10.1093/ije/dyv081
work_keys_str_mv AT gardnerreneem maternalbodymassindexduringearlypregnancygestationalweightgainandriskofautismspectrumdisordersresultsfromaswedishtotalpopulationanddiscordantsiblingstudy
AT leebriank maternalbodymassindexduringearlypregnancygestationalweightgainandriskofautismspectrumdisordersresultsfromaswedishtotalpopulationanddiscordantsiblingstudy
AT magnussoncecilia maternalbodymassindexduringearlypregnancygestationalweightgainandriskofautismspectrumdisordersresultsfromaswedishtotalpopulationanddiscordantsiblingstudy
AT raidheeraj maternalbodymassindexduringearlypregnancygestationalweightgainandriskofautismspectrumdisordersresultsfromaswedishtotalpopulationanddiscordantsiblingstudy
AT frisellthomas maternalbodymassindexduringearlypregnancygestationalweightgainandriskofautismspectrumdisordersresultsfromaswedishtotalpopulationanddiscordantsiblingstudy
AT karlssonhakan maternalbodymassindexduringearlypregnancygestationalweightgainandriskofautismspectrumdisordersresultsfromaswedishtotalpopulationanddiscordantsiblingstudy
AT idringselma maternalbodymassindexduringearlypregnancygestationalweightgainandriskofautismspectrumdisordersresultsfromaswedishtotalpopulationanddiscordantsiblingstudy
AT dalmanchristina maternalbodymassindexduringearlypregnancygestationalweightgainandriskofautismspectrumdisordersresultsfromaswedishtotalpopulationanddiscordantsiblingstudy