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Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

The insulin-degrading enzyme (IDE) degrades amyloidogenic proteins such as Amyloid β (Αβ) and Islet Amyloid Polypeptide (IAPP), i.e. peptides associated with Alzheimer’s disease and type 2 diabetes, respectively. In addition to the protease activity normally associated with IDE function an additiona...

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Detalles Bibliográficos
Autores principales:	Sharma, Sandeep K., Chorell, Erik, Steneberg, Pär, Vernersson-Lindahl, Emma, Edlund, Helena, Wittung-Stafshede, Pernilla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521159/ https://www.ncbi.nlm.nih.gov/pubmed/26228656 http://dx.doi.org/10.1038/srep12531

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