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Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next?

Tacrolimus and cyclosporine have been used in various formulations, but their hypersensitivity reactions are rare in practice. Castor oil derivatives are nonionic surfactants used in aqueous preparations of hydrophobic active pharmaceutical ingredients. Castor oil derivatives that can be used as add...

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Autores principales: Kang, Sung-Yoon, Sohn, Kyoung-Hee, Lee, Jeong-Ok, Kim, Sae-Hoon, Cho, Sang-Heon, Chang, Yoon-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521168/
https://www.ncbi.nlm.nih.gov/pubmed/26240796
http://dx.doi.org/10.5415/apallergy.2015.5.3.181
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author Kang, Sung-Yoon
Sohn, Kyoung-Hee
Lee, Jeong-Ok
Kim, Sae-Hoon
Cho, Sang-Heon
Chang, Yoon-Seok
author_facet Kang, Sung-Yoon
Sohn, Kyoung-Hee
Lee, Jeong-Ok
Kim, Sae-Hoon
Cho, Sang-Heon
Chang, Yoon-Seok
author_sort Kang, Sung-Yoon
collection PubMed
description Tacrolimus and cyclosporine have been used in various formulations, but their hypersensitivity reactions are rare in practice. Castor oil derivatives are nonionic surfactants used in aqueous preparations of hydrophobic active pharmaceutical ingredients. Castor oil derivatives that can be used as additives to tacrolimus and cyclosporine may play a role in the development of hypersensitivity reactions, especially anaphylaxis. Various immunologic and nonimmunologic mechanisms have been implicated in hypersensitivity reactions induced by castor oil derivatives. Physicians should be aware that not only the drug itself, but also its additives or metabolites could induce hypersensitivity reactions. We report a case of anaphylaxis caused by vitamin K (phytonadine), serotonin antagonist (granisetron), intravenous tacrolimus, and cyclosporine. Interestingly, the patient tolerated oral cyclosporine, which did not contain Cremophor EL or polysorbate 80.
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spelling pubmed-45211682015-08-03 Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next? Kang, Sung-Yoon Sohn, Kyoung-Hee Lee, Jeong-Ok Kim, Sae-Hoon Cho, Sang-Heon Chang, Yoon-Seok Asia Pac Allergy Educational & Teaching Material Tacrolimus and cyclosporine have been used in various formulations, but their hypersensitivity reactions are rare in practice. Castor oil derivatives are nonionic surfactants used in aqueous preparations of hydrophobic active pharmaceutical ingredients. Castor oil derivatives that can be used as additives to tacrolimus and cyclosporine may play a role in the development of hypersensitivity reactions, especially anaphylaxis. Various immunologic and nonimmunologic mechanisms have been implicated in hypersensitivity reactions induced by castor oil derivatives. Physicians should be aware that not only the drug itself, but also its additives or metabolites could induce hypersensitivity reactions. We report a case of anaphylaxis caused by vitamin K (phytonadine), serotonin antagonist (granisetron), intravenous tacrolimus, and cyclosporine. Interestingly, the patient tolerated oral cyclosporine, which did not contain Cremophor EL or polysorbate 80. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2015-07 2015-07-29 /pmc/articles/PMC4521168/ /pubmed/26240796 http://dx.doi.org/10.5415/apallergy.2015.5.3.181 Text en Copyright © 2015. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Educational & Teaching Material
Kang, Sung-Yoon
Sohn, Kyoung-Hee
Lee, Jeong-Ok
Kim, Sae-Hoon
Cho, Sang-Heon
Chang, Yoon-Seok
Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next?
title Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next?
title_full Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next?
title_fullStr Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next?
title_full_unstemmed Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next?
title_short Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next?
title_sort intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next?
topic Educational & Teaching Material
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521168/
https://www.ncbi.nlm.nih.gov/pubmed/26240796
http://dx.doi.org/10.5415/apallergy.2015.5.3.181
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