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Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next?
Tacrolimus and cyclosporine have been used in various formulations, but their hypersensitivity reactions are rare in practice. Castor oil derivatives are nonionic surfactants used in aqueous preparations of hydrophobic active pharmaceutical ingredients. Castor oil derivatives that can be used as add...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521168/ https://www.ncbi.nlm.nih.gov/pubmed/26240796 http://dx.doi.org/10.5415/apallergy.2015.5.3.181 |
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author | Kang, Sung-Yoon Sohn, Kyoung-Hee Lee, Jeong-Ok Kim, Sae-Hoon Cho, Sang-Heon Chang, Yoon-Seok |
author_facet | Kang, Sung-Yoon Sohn, Kyoung-Hee Lee, Jeong-Ok Kim, Sae-Hoon Cho, Sang-Heon Chang, Yoon-Seok |
author_sort | Kang, Sung-Yoon |
collection | PubMed |
description | Tacrolimus and cyclosporine have been used in various formulations, but their hypersensitivity reactions are rare in practice. Castor oil derivatives are nonionic surfactants used in aqueous preparations of hydrophobic active pharmaceutical ingredients. Castor oil derivatives that can be used as additives to tacrolimus and cyclosporine may play a role in the development of hypersensitivity reactions, especially anaphylaxis. Various immunologic and nonimmunologic mechanisms have been implicated in hypersensitivity reactions induced by castor oil derivatives. Physicians should be aware that not only the drug itself, but also its additives or metabolites could induce hypersensitivity reactions. We report a case of anaphylaxis caused by vitamin K (phytonadine), serotonin antagonist (granisetron), intravenous tacrolimus, and cyclosporine. Interestingly, the patient tolerated oral cyclosporine, which did not contain Cremophor EL or polysorbate 80. |
format | Online Article Text |
id | pubmed-4521168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-45211682015-08-03 Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next? Kang, Sung-Yoon Sohn, Kyoung-Hee Lee, Jeong-Ok Kim, Sae-Hoon Cho, Sang-Heon Chang, Yoon-Seok Asia Pac Allergy Educational & Teaching Material Tacrolimus and cyclosporine have been used in various formulations, but their hypersensitivity reactions are rare in practice. Castor oil derivatives are nonionic surfactants used in aqueous preparations of hydrophobic active pharmaceutical ingredients. Castor oil derivatives that can be used as additives to tacrolimus and cyclosporine may play a role in the development of hypersensitivity reactions, especially anaphylaxis. Various immunologic and nonimmunologic mechanisms have been implicated in hypersensitivity reactions induced by castor oil derivatives. Physicians should be aware that not only the drug itself, but also its additives or metabolites could induce hypersensitivity reactions. We report a case of anaphylaxis caused by vitamin K (phytonadine), serotonin antagonist (granisetron), intravenous tacrolimus, and cyclosporine. Interestingly, the patient tolerated oral cyclosporine, which did not contain Cremophor EL or polysorbate 80. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2015-07 2015-07-29 /pmc/articles/PMC4521168/ /pubmed/26240796 http://dx.doi.org/10.5415/apallergy.2015.5.3.181 Text en Copyright © 2015. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Educational & Teaching Material Kang, Sung-Yoon Sohn, Kyoung-Hee Lee, Jeong-Ok Kim, Sae-Hoon Cho, Sang-Heon Chang, Yoon-Seok Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next? |
title | Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next? |
title_full | Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next? |
title_fullStr | Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next? |
title_full_unstemmed | Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next? |
title_short | Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next? |
title_sort | intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next? |
topic | Educational & Teaching Material |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521168/ https://www.ncbi.nlm.nih.gov/pubmed/26240796 http://dx.doi.org/10.5415/apallergy.2015.5.3.181 |
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