Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis

The relationship between the neutrophil-to-lymphocyte ratio (NLR) and tumours as a prognostic factor has been reported in many studies. In this meta-analysis, we evaluated the prognostic role of the NLR in pancreatic cancer (PC). A systematic search was performed in PubMed and Embase for relevant st...

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Autores principales: Cheng, Hao, Long, Feiwu, Jaiswar, Mukesh, Yang, Lie, Wang, Cun, Zhou, Zongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521184/
https://www.ncbi.nlm.nih.gov/pubmed/26226887
http://dx.doi.org/10.1038/srep11026
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author Cheng, Hao
Long, Feiwu
Jaiswar, Mukesh
Yang, Lie
Wang, Cun
Zhou, Zongguang
author_facet Cheng, Hao
Long, Feiwu
Jaiswar, Mukesh
Yang, Lie
Wang, Cun
Zhou, Zongguang
author_sort Cheng, Hao
collection PubMed
description The relationship between the neutrophil-to-lymphocyte ratio (NLR) and tumours as a prognostic factor has been reported in many studies. In this meta-analysis, we evaluated the prognostic role of the NLR in pancreatic cancer (PC). A systematic search was performed in PubMed and Embase for relevant studies. Data from and characteristics of each study were extracted. A meta-analysis was performed to analyse the prognostic role of the NLR using the hazard ratio (HR) and 95% confidence intervals (95% CI). As a result, a total of 2035 patients in 9 cohorts were included in this meta-analysis. The pooled HR of 1.587 (95% CI: 1.411–1.785, p < 0.01) showed that patients with an elevated NLR were expected to have shorter overall survival (OS) after treatment. This meta-analysis suggests that an elevated NLR can be used as a predictor of survival in patients with pancreatic cancer.
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spelling pubmed-45211842015-08-05 Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis Cheng, Hao Long, Feiwu Jaiswar, Mukesh Yang, Lie Wang, Cun Zhou, Zongguang Sci Rep Article The relationship between the neutrophil-to-lymphocyte ratio (NLR) and tumours as a prognostic factor has been reported in many studies. In this meta-analysis, we evaluated the prognostic role of the NLR in pancreatic cancer (PC). A systematic search was performed in PubMed and Embase for relevant studies. Data from and characteristics of each study were extracted. A meta-analysis was performed to analyse the prognostic role of the NLR using the hazard ratio (HR) and 95% confidence intervals (95% CI). As a result, a total of 2035 patients in 9 cohorts were included in this meta-analysis. The pooled HR of 1.587 (95% CI: 1.411–1.785, p < 0.01) showed that patients with an elevated NLR were expected to have shorter overall survival (OS) after treatment. This meta-analysis suggests that an elevated NLR can be used as a predictor of survival in patients with pancreatic cancer. Nature Publishing Group 2015-07-31 /pmc/articles/PMC4521184/ /pubmed/26226887 http://dx.doi.org/10.1038/srep11026 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Cheng, Hao
Long, Feiwu
Jaiswar, Mukesh
Yang, Lie
Wang, Cun
Zhou, Zongguang
Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis
title Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis
title_full Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis
title_fullStr Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis
title_full_unstemmed Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis
title_short Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis
title_sort prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521184/
https://www.ncbi.nlm.nih.gov/pubmed/26226887
http://dx.doi.org/10.1038/srep11026
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