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Thrombosis Associated with Viral Hepatitis
Viral hepatitis may promote the development of venous thromboembolism (VTE) and, more specifically, portal vein thrombosis (PVT). In this narrative review, we summarize the clinical data and discuss the possible pathogenetic roles of cytomegalovirus (CMV), Epstein-Barr virus (EBV), and hepatitis A,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
XIA & HE Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521234/ https://www.ncbi.nlm.nih.gov/pubmed/26357629 http://dx.doi.org/10.14218/JCTH.2014.00031 |
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author | Galli, Luca Gerdes, Victor E.A. Guasti, Luigina Squizzato, Alessandro |
author_facet | Galli, Luca Gerdes, Victor E.A. Guasti, Luigina Squizzato, Alessandro |
author_sort | Galli, Luca |
collection | PubMed |
description | Viral hepatitis may promote the development of venous thromboembolism (VTE) and, more specifically, portal vein thrombosis (PVT). In this narrative review, we summarize the clinical data and discuss the possible pathogenetic roles of cytomegalovirus (CMV), Epstein-Barr virus (EBV), and hepatitis A, B, and C viruses (HAV, HBV, HCV) in the occurrence of VTE. CMV is the first qualified candidate to enter the list of VTE minor risk factors, and in the rare case of fulminant infection, both EBV and CMV, like any severe infection or inflammatory disease, increase risk for thrombosis. In chronic hepatitis B and C, it remains controversial whether antiphospholipid antibodies are important for thrombotic complications or merely an epiphenomenon. Retinal vein occlusion described in chronic hepatitis C is usually attributed to the treatment with interferon. Eltrombopag, used for HCV-related thrombocytopenia, has been associated with increased thrombotic risk. The imbalance between procoagulant and anticoagulant factors associated with chronic liver disease may have clinical implications. This may help to explain why these patients are not protected from clinical events such as VTE, PVT, and the progression of liver fibrosis. |
format | Online Article Text |
id | pubmed-4521234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | XIA & HE Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45212342015-09-09 Thrombosis Associated with Viral Hepatitis Galli, Luca Gerdes, Victor E.A. Guasti, Luigina Squizzato, Alessandro J Clin Transl Hepatol Review Article Viral hepatitis may promote the development of venous thromboembolism (VTE) and, more specifically, portal vein thrombosis (PVT). In this narrative review, we summarize the clinical data and discuss the possible pathogenetic roles of cytomegalovirus (CMV), Epstein-Barr virus (EBV), and hepatitis A, B, and C viruses (HAV, HBV, HCV) in the occurrence of VTE. CMV is the first qualified candidate to enter the list of VTE minor risk factors, and in the rare case of fulminant infection, both EBV and CMV, like any severe infection or inflammatory disease, increase risk for thrombosis. In chronic hepatitis B and C, it remains controversial whether antiphospholipid antibodies are important for thrombotic complications or merely an epiphenomenon. Retinal vein occlusion described in chronic hepatitis C is usually attributed to the treatment with interferon. Eltrombopag, used for HCV-related thrombocytopenia, has been associated with increased thrombotic risk. The imbalance between procoagulant and anticoagulant factors associated with chronic liver disease may have clinical implications. This may help to explain why these patients are not protected from clinical events such as VTE, PVT, and the progression of liver fibrosis. XIA & HE Publishing Ltd 2014-12-15 2014-12 /pmc/articles/PMC4521234/ /pubmed/26357629 http://dx.doi.org/10.14218/JCTH.2014.00031 Text en © 2014 The Second Affiliated Hospital of Chongqing Medical University. Published by XIA & HE Publishing Ltd. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Galli, Luca Gerdes, Victor E.A. Guasti, Luigina Squizzato, Alessandro Thrombosis Associated with Viral Hepatitis |
title | Thrombosis Associated with Viral Hepatitis |
title_full | Thrombosis Associated with Viral Hepatitis |
title_fullStr | Thrombosis Associated with Viral Hepatitis |
title_full_unstemmed | Thrombosis Associated with Viral Hepatitis |
title_short | Thrombosis Associated with Viral Hepatitis |
title_sort | thrombosis associated with viral hepatitis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521234/ https://www.ncbi.nlm.nih.gov/pubmed/26357629 http://dx.doi.org/10.14218/JCTH.2014.00031 |
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