Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus: What is New?

Hepatitis B virus (HBV) causes an endemic infection that affects nearly 2 billion patients worldwide. It is one of the leading causes of liver cirrhosis, hepatocellular carcinoma (HCC), and liver transplantation (LT). Recurrence of HBV infection after LT is due to specific HBV-host genome interactio...

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Detalles Bibliográficos
Autores principales: Harmancı, Özgür, Selçuk, Haldun, Haberal, Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Ltd 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521236/
https://www.ncbi.nlm.nih.gov/pubmed/26356785
http://dx.doi.org/10.14218/JCTH.2014.00023
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author Harmancı, Özgür
Selçuk, Haldun
Haberal, Mehmet
author_facet Harmancı, Özgür
Selçuk, Haldun
Haberal, Mehmet
author_sort Harmancı, Özgür
collection PubMed
description Hepatitis B virus (HBV) causes an endemic infection that affects nearly 2 billion patients worldwide. It is one of the leading causes of liver cirrhosis, hepatocellular carcinoma (HCC), and liver transplantation (LT). Recurrence of HBV infection after LT is due to specific HBV-host genome interactions. Although hepatitis B immunoglobulin treatment constituted the backbone of HBV recurrence, use of the nucleoside and nucleotide analogs (especially the ones with a higher genetic barrier to resistance), either alone or in combination, offer us new and powerful options in overcoming this serious issue.
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spelling pubmed-45212362015-09-09 Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus: What is New? Harmancı, Özgür Selçuk, Haldun Haberal, Mehmet J Clin Transl Hepatol Review Article Hepatitis B virus (HBV) causes an endemic infection that affects nearly 2 billion patients worldwide. It is one of the leading causes of liver cirrhosis, hepatocellular carcinoma (HCC), and liver transplantation (LT). Recurrence of HBV infection after LT is due to specific HBV-host genome interactions. Although hepatitis B immunoglobulin treatment constituted the backbone of HBV recurrence, use of the nucleoside and nucleotide analogs (especially the ones with a higher genetic barrier to resistance), either alone or in combination, offer us new and powerful options in overcoming this serious issue. XIA & HE Publishing Ltd 2014-12-15 2014-12 /pmc/articles/PMC4521236/ /pubmed/26356785 http://dx.doi.org/10.14218/JCTH.2014.00023 Text en © 2014 The Second Affiliated Hospital of Chongqing Medical University. Published by XIA & HE Publishing Ltd. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Harmancı, Özgür
Selçuk, Haldun
Haberal, Mehmet
Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus: What is New?
title Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus: What is New?
title_full Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus: What is New?
title_fullStr Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus: What is New?
title_full_unstemmed Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus: What is New?
title_short Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus: What is New?
title_sort prophylaxis against recurrence in liver transplantation patients with hepatitis b virus: what is new?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521236/
https://www.ncbi.nlm.nih.gov/pubmed/26356785
http://dx.doi.org/10.14218/JCTH.2014.00023
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