Cargando…

KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia

BACKGROUND: Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets. KCNQ channels, a subfamily of voltage-gated K(+) channels mediating M-currents, play a key role in neuro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abd-Elsayed, Alaa A, Ikeda, Ryo, Jia, Zhanfeng, Ling, Jennifer, Zuo, Xiaozhuo, Li, Min, Gu, Jianguo G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521366/ https://www.ncbi.nlm.nih.gov/pubmed/26227020 http://dx.doi.org/10.1186/s12990-015-0048-8

Ejemplares similares

Operant behavioral responses to orofacial cold stimuli in rats with chronic constrictive trigeminal nerve injury: effects of menthol and capsazepine
por: Zuo, Xiaozhuo, et al.
Publicado: (2013)

Study of chronic orofacial pain with preclinical models
por: ABD-Elsayed, Alaa, et al.
Publicado: (2014)

Orofacial neuropathic pain induced by oxaliplatin: Downregulation of KCNQ2 channels in V2 trigeminal ganglion neurons and treatment by the KCNQ2 channel potentiator retigabine
por: Ling, Jennifer, et al.
Publicado: (2017)

Trigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury
por: Chai, Bryan, et al.
Publicado: (2012)

Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats
por: Allchorne, Andrew J, et al.
Publicado: (2005)

New Insights in Trigeminal Anatomy: A Double Orofacial Tract for Nociceptive Input
por: Henssen, Dylan J. H. A., et al.
Publicado: (2016)

Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs
por: Itou, Haruka, et al.
Publicado: (2022)

Gabapentin enhances anti-nociceptive effects of morphine on heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain
por: Hamidi, Gholam Ali, et al.
Publicado: (2014)

CGRP Induces Differential Regulation of Cytokines from Satellite Glial Cells in Trigeminal Ganglia and Orofacial Nociception
por: Afroz, Shaista, et al.
Publicado: (2019)

Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia
por: Vit, Jean-Philippe, et al.
Publicado: (2009)

Neural substrates of cold nociception in Drosophila larva
por: Patel, Atit A., et al.
Publicado: (2023)

Orofacial inflammatory pain affects the expression of MT1 and NADPH-d in rat caudal spinal trigeminal nucleus and trigeminal ganglion
por: Huang, Fang, et al.
Publicado: (2013)

Chemokine receptor CXCR2 in primary sensory neurons of trigeminal ganglion mediates orofacial itch
por: Li, Dong-Jin, et al.
Publicado: (2023)

Inflammatory Orofacial Pain Activates Peptidergic Neurons and Upregulates the Oxytocin Receptor Expression in Trigeminal Ganglion
por: Kemenesi-Gedei, Péter Bátor, et al.
Publicado: (2023)

Effects of cooling temperatures and low pH on membrane properties and voltage-dependent currents of rat nociceptive-like trigeminal ganglion neurons
por: Viatchenko-Karpinski, Viacheslav, et al.
Publicado: (2018)

Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold
por: Moss, Penny, et al.
Publicado: (2016)

Rapamycin reduces orofacial nociceptive responses and microglial p38 mitogen-activated protein kinase phosphorylation in trigeminal nucleus caudalis in mouse orofacial formalin model
por: Yeo, Ji-Hee, et al.
Publicado: (2021)

Transcriptional Alterations of Mouse Trigeminal Ganglion Neurons Following Orofacial Inflammation Revealed by Single-Cell Analysis
por: Liu, Qing, et al.
Publicado: (2022)

Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors
por: Shimizu, Kohei, et al.
Publicado: (2009)

Estradiol upregulates voltage-gated sodium channel 1.7 in trigeminal ganglion contributing to hyperalgesia of inflamed TMJ
por: Bi, Rui-Yun, et al.
Publicado: (2017)

Descending serotonergic modulation from rostral ventromedial medulla to spinal trigeminal nucleus is involved in experimental occlusal interference-induced chronic orofacial hyperalgesia
por: Mo, Si-Yi, et al.
Publicado: (2023)

GTP-dependent run-up of Piezo2-type mechanically activated currents in rat dorsal root ganglion neurons
por: Jia, Zhanfeng, et al.
Publicado: (2013)

Characterization of cold sensitivity and thermal preference using an operant orofacial assay
por: Rossi, Heather L, et al.
Publicado: (2006)

Liquiritigenin alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model
por: Chen, Li, et al.
Publicado: (2014)

Neurochemical Properties of the Synapses in the Pathways of Orofacial Nociceptive Reflexes
por: Dong, Yu-lin, et al.
Publicado: (2012)

Suppression of hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia following systemic administration of lutein via inhibition of cyclooxygenase-2 cascade signaling
por: Syoji, Yumiko, et al.
Publicado: (2018)

Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice
por: Zhang, Qian, et al.
Publicado: (2016)

Orofacial skin inflammation increases the number of macrophages in the maxillary subregion of the rat trigeminal ganglion in a corticosteroid-reversible manner
por: Legradi, Adam, et al.
Publicado: (2020)

Toll-like receptor 4 signaling in neurons of trigeminal ganglion contributes to nociception induced by acute pulpitis in rats
por: Lin, Jia-Ji, et al.
Publicado: (2015)

Intrathecal TRPM8 blocking attenuates cold hyperalgesia via PKC and NF-κB signaling in the dorsal root ganglion of rats with neuropathic pain
por: Cao, Song, et al.
Publicado: (2019)

Non-nociceptive and nociceptive-like trigeminal Aβ-afferent neurons of rats: Distinct electrophysiological properties, mechanical and chemical sensitivity
por: Vaden, Ryan J, et al.
Publicado: (2023)

Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats
por: Honda, Kuniya, et al.
Publicado: (2011)

Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia
por: Prochazkova, Michaela, et al.
Publicado: (2013)

Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress
por: Li, Yue-Xin, et al.
Publicado: (2022)

Chronic cobalt exposure modifies nociception and orofacial inflammatory pain
por: Alexa, T, et al.
Publicado: (2013)

Dexmedetomidine Co-Administered with Lidocaine Decreases Nociceptive Responses and Trigeminal Fos Expression without Motor Dysfunction and Hypotension in a Murine Orofacial Formalin Model
por: Yeo, Ji-Hee, et al.
Publicado: (2022)

Contribution of central sensitization to stress-induced spreading hyperalgesia in rats with orofacial inflammation
por: Li, Jia-Heng, et al.
Publicado: (2020)

Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia
por: Rinwa, Puneet, et al.
Publicado: (2021)

NEMATOSOMES IN THE RAT TRIGEMINAL GANGLION
por: Peach, Roy
Publicado: (1972)

TRPV1 activity and substance P release are required for corneal cold nociception
por: Li, Fengxian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_573h62lo8hd69hr5sjmaq4n2jk