Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer’s disease cybrid cells

BACKGROUND: Alzheimer’s disease (AD) is associated with vascular risk factors; brain ischemia facilitates the pathogenesis of AD. Recent studies have suggested that the reduction of AD risk with statin was achieved by decreased amyloidogenic amyloid precursor protein. METHODS: We used mitochondrial...

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Detalles Bibliográficos
Autores principales: Jeong, Jin-Heon, Yum, Kyu Sun, Chang, Jun Young, Kim, Manho, Ahn, Jin-young, Kim, SangYun, Lapchak, Paul A, Han, Moon-Ku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521481/
https://www.ncbi.nlm.nih.gov/pubmed/26228060
http://dx.doi.org/10.1186/s12883-015-0390-5

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