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Trust behavior in Parkinson’s disease: results of a trust game experiment
BACKGROUND: Parkinson’s Disease (PD) is a neurodegenerative disease characterized by motor symptoms, but in which behavioral and cognitive disturbances are also common. Trust, due to its pervasiveness in society, has become a major research topic in several scientific disciplines. However, empirical...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521483/ https://www.ncbi.nlm.nih.gov/pubmed/26227627 http://dx.doi.org/10.1186/s12883-015-0374-5 |
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author | Javor, Andrija Riedl, René Kirchmayr, Matthias Reichenberger, Mirella Ransmayr, Gerhard |
author_facet | Javor, Andrija Riedl, René Kirchmayr, Matthias Reichenberger, Mirella Ransmayr, Gerhard |
author_sort | Javor, Andrija |
collection | PubMed |
description | BACKGROUND: Parkinson’s Disease (PD) is a neurodegenerative disease characterized by motor symptoms, but in which behavioral and cognitive disturbances are also common. Trust, due to its pervasiveness in society, has become a major research topic in several scientific disciplines. However, empirical evidence for trust behavior in neurological patients, and specifically for movement disorders such as PD, is missing. Evidence from healthy subjects, however, indicates that three brain regions are involved in trust perceptions and behavior, namely the limbic system, basal ganglia, and frontal cortex. PD affects all these brain regions. Therefore, we hypothesized that PD patients and healthy controls show differences in trust behavior. METHODS: We conducted an experiment using the trust game, an established paradigm to investigate trust behavior in both patient and healthy populations alike, controlling for risky decision making. Twenty patients suffering from PD diagnosed according to UK PDS Brain Bank criteria and twenty healthy controls (matched for age, gender, education, and income) were recruited. We excluded those suffering from clinically relevant neuropsychiatric comorbidities. RESULTS: We found that PD patients exhibit significantly lower levels of trust than do healthy controls. Importantly, our results cannot be explained by lower levels of risk-taking. Moreover, our results indicate that the trust deficit is independent of medication, disease duration, and severity of motor symptoms. CONCLUSION: Application of a standard procedure for measuring trust behavior revealed that PD patients exhibit lower levels of trust in other humans than do healthy controls. Against this background we make a call for further research to determine the underlying pathophysiology of reduced trust in PD. |
format | Online Article Text |
id | pubmed-4521483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45214832015-08-01 Trust behavior in Parkinson’s disease: results of a trust game experiment Javor, Andrija Riedl, René Kirchmayr, Matthias Reichenberger, Mirella Ransmayr, Gerhard BMC Neurol Research Article BACKGROUND: Parkinson’s Disease (PD) is a neurodegenerative disease characterized by motor symptoms, but in which behavioral and cognitive disturbances are also common. Trust, due to its pervasiveness in society, has become a major research topic in several scientific disciplines. However, empirical evidence for trust behavior in neurological patients, and specifically for movement disorders such as PD, is missing. Evidence from healthy subjects, however, indicates that three brain regions are involved in trust perceptions and behavior, namely the limbic system, basal ganglia, and frontal cortex. PD affects all these brain regions. Therefore, we hypothesized that PD patients and healthy controls show differences in trust behavior. METHODS: We conducted an experiment using the trust game, an established paradigm to investigate trust behavior in both patient and healthy populations alike, controlling for risky decision making. Twenty patients suffering from PD diagnosed according to UK PDS Brain Bank criteria and twenty healthy controls (matched for age, gender, education, and income) were recruited. We excluded those suffering from clinically relevant neuropsychiatric comorbidities. RESULTS: We found that PD patients exhibit significantly lower levels of trust than do healthy controls. Importantly, our results cannot be explained by lower levels of risk-taking. Moreover, our results indicate that the trust deficit is independent of medication, disease duration, and severity of motor symptoms. CONCLUSION: Application of a standard procedure for measuring trust behavior revealed that PD patients exhibit lower levels of trust in other humans than do healthy controls. Against this background we make a call for further research to determine the underlying pathophysiology of reduced trust in PD. BioMed Central 2015-07-31 /pmc/articles/PMC4521483/ /pubmed/26227627 http://dx.doi.org/10.1186/s12883-015-0374-5 Text en © Javor et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Javor, Andrija Riedl, René Kirchmayr, Matthias Reichenberger, Mirella Ransmayr, Gerhard Trust behavior in Parkinson’s disease: results of a trust game experiment |
title | Trust behavior in Parkinson’s disease: results of a trust game experiment |
title_full | Trust behavior in Parkinson’s disease: results of a trust game experiment |
title_fullStr | Trust behavior in Parkinson’s disease: results of a trust game experiment |
title_full_unstemmed | Trust behavior in Parkinson’s disease: results of a trust game experiment |
title_short | Trust behavior in Parkinson’s disease: results of a trust game experiment |
title_sort | trust behavior in parkinson’s disease: results of a trust game experiment |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521483/ https://www.ncbi.nlm.nih.gov/pubmed/26227627 http://dx.doi.org/10.1186/s12883-015-0374-5 |
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