Quantitative assessment of pre-miR-218 rs11134527 polymorphism and cancer risk in Chinese population

BACKGROUND: Accumulated studies have evaluated the association of pre-miR-218 rs11134527 polymorphism with cancer risk in Chinese population. However, the results remain controversial. METHODS: To derive a more precise and more comprehensive estimation of the relationship, six studies focused on Chinese population were included for the pooled analysis for pre-miR-218 rs11134527 polymorphism using odds ratios (ORs) with 95% confidence intervals (CIs). RESULTS: Pre-miR-218 rs11134527 polymorphism was associated with cancer risk (G versus A, OR =0.93, 95% CI: 0.88–0.98; GG versus AG + AA, OR =0.88, 95% CI: 0.79–0.97; GG versus AA, OR =0.85, 95% CI: 0.76–0.96). In the stratified analysis by cancer type, the pre-miR-218 rs11134527 polymorphism was only associated with the risk of cervical cancer (G versus A, OR =0.90, 95% CI: 0.83–0.98; GG versus AG + AA, OR =0.80, 95% CI: 0.68–0.94; GG versus AA, OR =0.79, 95% CI: 0.66–0.94). CONCLUSION: These findings suggest that the pre-miR-218 rs11134527 genetic polymorphism may decrease the susceptibility to cervical cancer, which needs to be verified or linked with functional studies.