Cargando…

Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells

Withaferin A (WA), a major bioactive component of the Indian herb Withania somnifera, induces cell death (apoptosis/necrosis) in multiple types of tumor cells, but the molecular mechanism underlying this cytotoxicity remains elusive. We report here that 2 μM WA induced cell death selectively in andr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nishikawa, Yukihiro, Okuzaki, Daisuke, Fukushima, Kohshiro, Mukai, Satomi, Ohno, Shouichi, Ozaki, Yuki, Yabuta, Norikazu, Nojima, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521694/ https://www.ncbi.nlm.nih.gov/pubmed/26230090 http://dx.doi.org/10.1371/journal.pone.0134137

Ejemplares similares

ELAS1 induces apoptotic death in adenocarcinoma DU145 and squamous-cell carcinoma SAS cancer cells, but not in normal KD cells
por: Uchihashi, Toshihiro, et al.
Publicado: (2017)

Late cornified envelope 1C (LCE1C), a transcriptional target of TAp63 phosphorylated at T46/T281, interacts with PRMT5
por: Yabuta, Norikazu, et al.
Publicado: (2018)

Comprehensive phenotypic analysis of knockout mice deficient in cyclin G1 and cyclin G2
por: Ohno, Shouichi, et al.
Publicado: (2016)

LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer
por: Nozaki, Masami, et al.
Publicado: (2019)

LATS2 Positively Regulates Polycomb Repressive Complex 2
por: Torigata, Kosuke, et al.
Publicado: (2016)

LeukoCatch, a quick and efficient tool for the preparation of leukocyte extracts from blood
por: Okuzaki, Daisuke, et al.
Publicado: (2011)

Gefitinib and Luteolin Cause Growth Arrest of Human Prostate Cancer PC-3 Cells via Inhibition of Cyclin G-Associated Kinase and Induction of miR-630
por: Sakurai, Minami A., et al.
Publicado: (2014)

Microarray and whole-exome sequencing analysis of familial Behçet’s disease patients
por: Okuzaki, Daisuke, et al.
Publicado: (2016)

Large tumor suppressors 1 and 2 regulate Aurora-B through phosphorylation of INCENP to ensure completion of cytokinesis
por: Yabuta, Norikazu, et al.
Publicado: (2016)

Isolation of cancer cells with augmented spheroid-forming capability using a novel tool equipped with removable filter
por: Fujibayashi, Emi, et al.
Publicado: (2018)

LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells
por: Fujibayashi, Emi, et al.
Publicado: (2022)

Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association with Cell Shape and Cytoskeletal Modifications
por: Hagiyama, Man, et al.
Publicado: (2017)

FCN1 (M-ficolin), which directly associates with immunoglobulin G1, is a molecular target of intravenous immunoglobulin therapy for Kawasaki disease
por: Okuzaki, Daisuke, et al.
Publicado: (2017)

Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B
por: Mukai, Satomi, et al.
Publicado: (2015)

Expression Profiling of PBMC-based Diagnostic Gene Markers Isolated from Vasculitis Patients
por: Kobayashi, Shigeto, et al.
Publicado: (2008)

Neonatal Lethality in Knockout Mice Expressing the Kinase-Dead Form of the Gefitinib Target GAK Is Caused by Pulmonary Dysfunction
por: Tabara, Hiroe, et al.
Publicado: (2011)

Mcp5, a meiotic cell cortex protein, is required for nuclear movement mediated by dynein and microtubules in fission yeast
por: Saito, Takamune T., et al.
Publicado: (2006)

Chum-RNA allows preparation of a high-quality cDNA library from a single-cell quantity of mRNA without PCR amplification
por: Tougan, Takahiro, et al.
Publicado: (2008)

Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation
por: Aylon, Yael, et al.
Publicado: (2009)

Ficolin-1 is a promising therapeutic target for autoimmune diseases
por: Katayama, Michihito, et al.
Publicado: (2018)

Withaferin A Alters Intermediate Filament Organization, Cell Shape and Behavior
por: Grin, Boris, et al.
Publicado: (2012)

AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol
por: Jagannathan, Radhika, et al.
Publicado: (2016)

Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells
por: Suman, Suman, et al.
Publicado: (2016)

Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression
por: Okamoto, Shuichiro, et al.
Publicado: (2016)

Withaferin A inhibits Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells
por: Kyakulaga, Al Hassan, et al.
Publicado: (2018)

Implications of Withaferin A in neurological disorders
por: Ram, Natasha, et al.
Publicado: (2020)

Focused Microarray Analysis of Peripheral Mononuclear Blood Cells from Churg–Strauss Syndrome Patients
por: Tougan, Takahiro, et al.
Publicado: (2008)

Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells
por: Chen, Mengqian, et al.
Publicado: (2010)

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells
por: Kyakulaga, Al Hassan, et al.
Publicado: (2020)

Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences
por: Yu, Yue, et al.
Publicado: (2017)

Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species
por: Hahm, Eun-Ryeong, et al.
Publicado: (2011)

Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple Myeloma
por: Yco, Lisette P, et al.
Publicado: (2014)

Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity
por: Choi, Bu Young, et al.
Publicado: (2015)

Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells
por: Kakar, Sham S., et al.
Publicado: (2017)

Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells
por: Chang, Hsueh-Wei, et al.
Publicado: (2017)

Loss of Fibroblast-Dependent Androgen Receptor Activation in Prostate Cancer Cells is Involved in the Mechanism of Acquired Resistance to Castration
por: Ishii, Kenichiro, et al.
Publicado: (2019)

Withaferin A Associated Differential Regulation of Inflammatory Cytokines
por: Dubey, Seema, et al.
Publicado: (2018)

Evaluation of the geroprotective effects of withaferin A in Drosophila melanogaster
por: Koval, Liubov, et al.
Publicado: (2021)

Genopal™: A Novel Hollow Fibre Array for Focused Microarray Analysis
por: Okuzaki, Daisuke, et al.
Publicado: (2010)

Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
por: Niemira, Magdalena, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_h9asrckd26e53ts7f3k0ieq788