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Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma

PURPOSE: To accurately map the retinal area covered by tumor in a prospectively enrolled cohort of children diagnosed with retinoblastoma. METHODS: Orbital MRI in 106 consecutive retinoblastoma patients (44 bilateral) was analyzed. For MRI-visible tumors, the polar angle and angle of eccentricity of...

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Autores principales: King, Benjamin A., Parra, Carlos, Li, Yimei, Helton, Kathleen J., Qaddoumi, Ibrahim, Wilson, Matthew W., Ogg, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521796/
https://www.ncbi.nlm.nih.gov/pubmed/26230335
http://dx.doi.org/10.1371/journal.pone.0132932
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author King, Benjamin A.
Parra, Carlos
Li, Yimei
Helton, Kathleen J.
Qaddoumi, Ibrahim
Wilson, Matthew W.
Ogg, Robert J.
author_facet King, Benjamin A.
Parra, Carlos
Li, Yimei
Helton, Kathleen J.
Qaddoumi, Ibrahim
Wilson, Matthew W.
Ogg, Robert J.
author_sort King, Benjamin A.
collection PubMed
description PURPOSE: To accurately map the retinal area covered by tumor in a prospectively enrolled cohort of children diagnosed with retinoblastoma. METHODS: Orbital MRI in 106 consecutive retinoblastoma patients (44 bilateral) was analyzed. For MRI-visible tumors, the polar angle and angle of eccentricity of points defining tumor perimeter on the retina were determined by triangulation from images in three orthogonal planes. The centroid of the mapped area was calculated to approximate tumor origin, and the location and cumulative tumor burden were analyzed in relation to mutation type (germline vs. somatic), tumor area, and patient age at diagnosis. Location of small tumors undetected by MRI was approximated with fundoscopic images. RESULTS: Mapping was successful for 129 tumors in 91 eyes from 67 patients (39 bilateral, 43 germline mutation). Cumulative tumor burden was highest within the macula and posterior pole and was asymmetrically higher within the inferonasal periphery. Tumor incidence was lowest in the superotemporal periphery. Tumor location varied with age at diagnosis in a complex pattern. Tumor location was concentrated in the macula and superonasal periphery in patients <5.6 months, in the inferotemporal quadrant of the posterior pole in patients 5.6-8.8 months, in the inferonasal quadrant in patients 8.8-13.2 months, and in the nasal and superotemporal periphery in patients >13.2 months. The distribution of MRI-invisible tumors was consistent with the asymmetry of mapped tumors. CONCLUSIONS: MRI-based mapping revealed a previously unrecognized pattern of retinoblastoma localization that evolves with age at diagnosis. The structured spatiotemporal distribution of tumors may provide valuable clues about cellular or molecular events associated with tumorigenesis in the developing retina.
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spelling pubmed-45217962015-08-06 Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma King, Benjamin A. Parra, Carlos Li, Yimei Helton, Kathleen J. Qaddoumi, Ibrahim Wilson, Matthew W. Ogg, Robert J. PLoS One Research Article PURPOSE: To accurately map the retinal area covered by tumor in a prospectively enrolled cohort of children diagnosed with retinoblastoma. METHODS: Orbital MRI in 106 consecutive retinoblastoma patients (44 bilateral) was analyzed. For MRI-visible tumors, the polar angle and angle of eccentricity of points defining tumor perimeter on the retina were determined by triangulation from images in three orthogonal planes. The centroid of the mapped area was calculated to approximate tumor origin, and the location and cumulative tumor burden were analyzed in relation to mutation type (germline vs. somatic), tumor area, and patient age at diagnosis. Location of small tumors undetected by MRI was approximated with fundoscopic images. RESULTS: Mapping was successful for 129 tumors in 91 eyes from 67 patients (39 bilateral, 43 germline mutation). Cumulative tumor burden was highest within the macula and posterior pole and was asymmetrically higher within the inferonasal periphery. Tumor incidence was lowest in the superotemporal periphery. Tumor location varied with age at diagnosis in a complex pattern. Tumor location was concentrated in the macula and superonasal periphery in patients <5.6 months, in the inferotemporal quadrant of the posterior pole in patients 5.6-8.8 months, in the inferonasal quadrant in patients 8.8-13.2 months, and in the nasal and superotemporal periphery in patients >13.2 months. The distribution of MRI-invisible tumors was consistent with the asymmetry of mapped tumors. CONCLUSIONS: MRI-based mapping revealed a previously unrecognized pattern of retinoblastoma localization that evolves with age at diagnosis. The structured spatiotemporal distribution of tumors may provide valuable clues about cellular or molecular events associated with tumorigenesis in the developing retina. Public Library of Science 2015-07-31 /pmc/articles/PMC4521796/ /pubmed/26230335 http://dx.doi.org/10.1371/journal.pone.0132932 Text en © 2015 King et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
King, Benjamin A.
Parra, Carlos
Li, Yimei
Helton, Kathleen J.
Qaddoumi, Ibrahim
Wilson, Matthew W.
Ogg, Robert J.
Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma
title Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma
title_full Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma
title_fullStr Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma
title_full_unstemmed Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma
title_short Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma
title_sort spatiotemporal patterns of tumor occurrence in children with intraocular retinoblastoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521796/
https://www.ncbi.nlm.nih.gov/pubmed/26230335
http://dx.doi.org/10.1371/journal.pone.0132932
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