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Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway

[Image: see text] The enzyme dihydrofolate reductase (DHFR, E) from Escherichia coli is a paradigm for the role of protein dynamics in enzyme catalysis. Previous studies have shown that the enzyme progresses through the kinetic cycle by modulating the dynamic conformational landscape in the presence...

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Detalles Bibliográficos
Autores principales:	Oyen, David, Fenwick, R. Bryn, Stanfield, Robyn L., Dyson, H. Jane, Wright, Peter E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521799/ https://www.ncbi.nlm.nih.gov/pubmed/26147643 http://dx.doi.org/10.1021/jacs.5b05707

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