Interdomain Contacts Control Native State Switching of RfaH on a Dual-Funneled Landscape

RfaH is a virulence factor from Escherichia coli whose C-terminal domain (CTD) undergoes a dramatic α-to-β conformational transformation. The CTD in its α-helical fold is stabilized by interactions with the N-terminal domain (NTD), masking an RNA polymerase binding site until a specific recruitment...

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Detalles Bibliográficos
Autores principales: Ramírez-Sarmiento, César A., Noel, Jeffrey K., Valenzuela, Sandro L., Artsimovitch, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521827/
https://www.ncbi.nlm.nih.gov/pubmed/26230837
http://dx.doi.org/10.1371/journal.pcbi.1004379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521827/
https://www.ncbi.nlm.nih.gov/pubmed/26230837
http://dx.doi.org/10.1371/journal.pcbi.1004379

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