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Interdomain Contacts Control Native State Switching of RfaH on a Dual-Funneled Landscape
RfaH is a virulence factor from Escherichia coli whose C-terminal domain (CTD) undergoes a dramatic α-to-β conformational transformation. The CTD in its α-helical fold is stabilized by interactions with the N-terminal domain (NTD), masking an RNA polymerase binding site until a specific recruitment...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521827/ https://www.ncbi.nlm.nih.gov/pubmed/26230837 http://dx.doi.org/10.1371/journal.pcbi.1004379 |