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Antibacterial and Antifungal Activity of ZnO Containing Glasses

A new family of non-toxic biocides based on low melting point (1250°C) transparent glasses with high content of ZnO (15–40wt%) belonging to the miscibility region of the B(2)O(3)-SiO(2)-Na(2)O-ZnO system has been developed. These glasses have shown an excellent biocide activity (logarithmic reductio...

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Autores principales: Esteban-Tejeda, Leticia, Prado, Catuxa, Cabal, Belén, Sanz, Jesús, Torrecillas, Ramón, Moya, José Serafín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521915/
https://www.ncbi.nlm.nih.gov/pubmed/26230940
http://dx.doi.org/10.1371/journal.pone.0132709
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author Esteban-Tejeda, Leticia
Prado, Catuxa
Cabal, Belén
Sanz, Jesús
Torrecillas, Ramón
Moya, José Serafín
author_facet Esteban-Tejeda, Leticia
Prado, Catuxa
Cabal, Belén
Sanz, Jesús
Torrecillas, Ramón
Moya, José Serafín
author_sort Esteban-Tejeda, Leticia
collection PubMed
description A new family of non-toxic biocides based on low melting point (1250°C) transparent glasses with high content of ZnO (15–40wt%) belonging to the miscibility region of the B(2)O(3)-SiO(2)-Na(2)O-ZnO system has been developed. These glasses have shown an excellent biocide activity (logarithmic reduction >3) against Gram- (E. coli), Gram+ (S. aureus) and yeast (C. krusei); they are chemically stable in different media (distilled water, sea-like water, LB and DMEN media) as well as biocompatible. The cytotoxicity was evaluated by the Neutral Red Uptake using NIH-3T3 (mouse embryonic fibroblast cells) and the cell viability was >80%. These new glasses can be considered in several and important applications in the field of inorganic non-toxic biocide agents such as medical implants, surgical equipment, protective apparels in hospitals, water purifications systems, food packaging, food storages or textiles.
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spelling pubmed-45219152015-08-06 Antibacterial and Antifungal Activity of ZnO Containing Glasses Esteban-Tejeda, Leticia Prado, Catuxa Cabal, Belén Sanz, Jesús Torrecillas, Ramón Moya, José Serafín PLoS One Research Article A new family of non-toxic biocides based on low melting point (1250°C) transparent glasses with high content of ZnO (15–40wt%) belonging to the miscibility region of the B(2)O(3)-SiO(2)-Na(2)O-ZnO system has been developed. These glasses have shown an excellent biocide activity (logarithmic reduction >3) against Gram- (E. coli), Gram+ (S. aureus) and yeast (C. krusei); they are chemically stable in different media (distilled water, sea-like water, LB and DMEN media) as well as biocompatible. The cytotoxicity was evaluated by the Neutral Red Uptake using NIH-3T3 (mouse embryonic fibroblast cells) and the cell viability was >80%. These new glasses can be considered in several and important applications in the field of inorganic non-toxic biocide agents such as medical implants, surgical equipment, protective apparels in hospitals, water purifications systems, food packaging, food storages or textiles. Public Library of Science 2015-07-31 /pmc/articles/PMC4521915/ /pubmed/26230940 http://dx.doi.org/10.1371/journal.pone.0132709 Text en © 2015 Esteban-Tejeda et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Esteban-Tejeda, Leticia
Prado, Catuxa
Cabal, Belén
Sanz, Jesús
Torrecillas, Ramón
Moya, José Serafín
Antibacterial and Antifungal Activity of ZnO Containing Glasses
title Antibacterial and Antifungal Activity of ZnO Containing Glasses
title_full Antibacterial and Antifungal Activity of ZnO Containing Glasses
title_fullStr Antibacterial and Antifungal Activity of ZnO Containing Glasses
title_full_unstemmed Antibacterial and Antifungal Activity of ZnO Containing Glasses
title_short Antibacterial and Antifungal Activity of ZnO Containing Glasses
title_sort antibacterial and antifungal activity of zno containing glasses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521915/
https://www.ncbi.nlm.nih.gov/pubmed/26230940
http://dx.doi.org/10.1371/journal.pone.0132709
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