Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim

BACKGROUND: Obatoclax is a clinical stage drug candidate that has been proposed to target and inhibit prosurvival members of the Bcl-2 family, and thereby contribute to cancer cell lethality. The insolubility of this compound, however, has precluded the use of many classical drug-target interaction...

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Autores principales: Nguyen, Mai, Cencic, Regina, Ertel, Franziska, Bernier, Cynthia, Pelletier, Jerry, Roulston, Anne, Silvius, John R., Shore, Gordon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522062/
https://www.ncbi.nlm.nih.gov/pubmed/26231047
http://dx.doi.org/10.1186/s12885-015-1582-5

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