Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

BACKGROUND: Microglia are dependent upon colony-stimulating factor 1 receptor (CSF1R) signaling for their survival in the adult brain, with administration of the dual CSF1R/c-kit inhibitor PLX3397 leading to the near-complete elimination of all microglia brainwide. Here, we determined the dose-depen...

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Detalles Bibliográficos
Autores principales: Dagher, Nabil N., Najafi, Allison R., Kayala, Kara M. Neely, Elmore, Monica R. P., White, Terra E., Medeiros, Rodrigo, West, Brian L., Green, Kim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522109/
https://www.ncbi.nlm.nih.gov/pubmed/26232154
http://dx.doi.org/10.1186/s12974-015-0366-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522109/
https://www.ncbi.nlm.nih.gov/pubmed/26232154
http://dx.doi.org/10.1186/s12974-015-0366-9

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