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Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding

The fourth conserved region (C4) in the HIV-1 envelope glycoprotein (Env) gp120 is a structural element that is important for its function, as it binds to both the receptor CD4 and the co-receptor CCR5/CXCR4. It has long been known that this region is highly immunogenic and that it harbors B-cell as...

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Detalles Bibliográficos
Autores principales:	Pan, Ruimin, Chen, Yuxin, Vaine, Michael, Hu, Guangnan, Wang, Shixia, Lu, Shan, Kong, Xiang-Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522616/ https://www.ncbi.nlm.nih.gov/pubmed/26251831 http://dx.doi.org/10.1038/emi.2015.44

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