Selective inhibitors of nuclear export avert progression in preclinical models of inflammatory demyelination

Axonal damage has been associated with aberrant protein trafficking. This study characterizes a novel class of compounds targeting nucleo-cytoplasmic shuttling, by binding to the catalytic groove of the nuclear export protein XPO1/CRM1 (chromosome region maintenance protein1). Oral administration of...

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Detalles Bibliográficos
Autores principales: Haines, Jeffery D., Herbin, Olivier, de la Hera, Belén, Vidaurre, Oscar G., Moy, Gregory A., Sun, Qingxiang, Fung, Ho Yee Joyce, Albrecht, Stephanie, Alexandropoulos, Konstantina, McCauley, Dilara, Chook, Yuh Min, Kuhlmann, Tanja, Kidd, Grahame J., Shacham, Sharon, Casaccia, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522902/
https://www.ncbi.nlm.nih.gov/pubmed/25706475
http://dx.doi.org/10.1038/nn.3953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522902/
https://www.ncbi.nlm.nih.gov/pubmed/25706475
http://dx.doi.org/10.1038/nn.3953

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