Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab resistance in primary HER2-positive breast cancer

BACKGROUND: The likelihood of recurrence in patients with breast cancer who have HER2-positive tumors is relatively high, although trastuzumab is a remarkably effective drug in this setting. Signal transducer and activator of transcription 3 protein (STAT3), a transcription factor that is persistent...

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Detalles Bibliográficos
Autores principales: Sonnenblick, Amir, Brohée, Sylvain, Fumagalli, Debora, Vincent, Delphine, Venet, David, Ignatiadis, Michail, Salgado, Roberto, Van den Eynden, Gert, Rothé, Françoise, Desmedt, Christine, Neven, Patrick, Loibl, Sibylle, Denkert, Carsten, Joensuu, Heikki, Loi, Sherene, Sirtaine, Nicolas, Kellokumpu-Lehtinen, Pirkko-Liisa, Piccart, Martine, Sotiriou, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522972/
https://www.ncbi.nlm.nih.gov/pubmed/26234940
http://dx.doi.org/10.1186/s12916-015-0416-2

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