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Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women
Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although toll-like receptors (TLRs), that are central to innate immune responses, may be i...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523061/ https://www.ncbi.nlm.nih.gov/pubmed/25928881 http://dx.doi.org/10.1038/gene.2015.13 |
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author | Mackelprang, Romel D. Scoville, Caitlin Wright Cohen, Craig R. Ondondo, Raphael Omusebe Bigham, Abigail W. Celum, Connie Campbell, Mary S. Essex, Max Wald, Anna Kiarie, James Ronald, Allan Gray, Glenda Lingappa, Jairam R. |
author_facet | Mackelprang, Romel D. Scoville, Caitlin Wright Cohen, Craig R. Ondondo, Raphael Omusebe Bigham, Abigail W. Celum, Connie Campbell, Mary S. Essex, Max Wald, Anna Kiarie, James Ronald, Allan Gray, Glenda Lingappa, Jairam R. |
author_sort | Mackelprang, Romel D. |
collection | PubMed |
description | Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although toll-like receptors (TLRs), that are central to innate immune responses, may be important. We evaluated associations between TLR SNPs and BV among HIV-1 infected and uninfected African women. Logistic regression was used to assess associations between SNPs (N=99) in TLRs 2-4, 7-9 and BV (as classified by Nugent's criteria). Among HIV-1 uninfected women, TLR7 rs5743737 and TLR7 rs1634323 were associated with a decreased risk of BV while TLR7 rs179012 was associated with an increased risk. TLR2 SNP rs3804099 was associated with a decreased risk of BV among HIV-1 infected women. Our findings indicate that there may be differences in TLR association with BV among HIV-1 infected and HIV-1 uninfected women. |
format | Online Article Text |
id | pubmed-4523061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-45230612016-01-01 Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women Mackelprang, Romel D. Scoville, Caitlin Wright Cohen, Craig R. Ondondo, Raphael Omusebe Bigham, Abigail W. Celum, Connie Campbell, Mary S. Essex, Max Wald, Anna Kiarie, James Ronald, Allan Gray, Glenda Lingappa, Jairam R. Genes Immun Article Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although toll-like receptors (TLRs), that are central to innate immune responses, may be important. We evaluated associations between TLR SNPs and BV among HIV-1 infected and uninfected African women. Logistic regression was used to assess associations between SNPs (N=99) in TLRs 2-4, 7-9 and BV (as classified by Nugent's criteria). Among HIV-1 uninfected women, TLR7 rs5743737 and TLR7 rs1634323 were associated with a decreased risk of BV while TLR7 rs179012 was associated with an increased risk. TLR2 SNP rs3804099 was associated with a decreased risk of BV among HIV-1 infected women. Our findings indicate that there may be differences in TLR association with BV among HIV-1 infected and HIV-1 uninfected women. 2015-04-30 2015 /pmc/articles/PMC4523061/ /pubmed/25928881 http://dx.doi.org/10.1038/gene.2015.13 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Mackelprang, Romel D. Scoville, Caitlin Wright Cohen, Craig R. Ondondo, Raphael Omusebe Bigham, Abigail W. Celum, Connie Campbell, Mary S. Essex, Max Wald, Anna Kiarie, James Ronald, Allan Gray, Glenda Lingappa, Jairam R. Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women |
title | Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women |
title_full | Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women |
title_fullStr | Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women |
title_full_unstemmed | Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women |
title_short | Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women |
title_sort | toll-like receptor gene variants and bacterial vaginosis among hiv-1 infected and uninfected african women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523061/ https://www.ncbi.nlm.nih.gov/pubmed/25928881 http://dx.doi.org/10.1038/gene.2015.13 |
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