Recent Molecular Advances in Our Understanding of Glioma

Our molecular understanding of glioma has undergone a sea change over the last decade. In this review, we discuss two recent articles that employed whole genome sequencing to subclassify gliomas vis-à-vis known molecular alterations. We further discuss the relevance of these findings vis-à-vis curre...

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Detalles Bibliográficos
Autores principales: Ramakrishna, Rohan, Pisapia, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523144/
https://www.ncbi.nlm.nih.gov/pubmed/26244119
http://dx.doi.org/10.7759/cureus.287
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author Ramakrishna, Rohan
Pisapia, David
author_facet Ramakrishna, Rohan
Pisapia, David
author_sort Ramakrishna, Rohan
collection PubMed
description Our molecular understanding of glioma has undergone a sea change over the last decade. In this review, we discuss two recent articles that employed whole genome sequencing to subclassify gliomas vis-à-vis known molecular alterations. We further discuss the relevance of these findings vis-à-vis current treatment paradigms.
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spelling pubmed-45231442015-08-04 Recent Molecular Advances in Our Understanding of Glioma Ramakrishna, Rohan Pisapia, David Cureus Oncology Our molecular understanding of glioma has undergone a sea change over the last decade. In this review, we discuss two recent articles that employed whole genome sequencing to subclassify gliomas vis-à-vis known molecular alterations. We further discuss the relevance of these findings vis-à-vis current treatment paradigms. Cureus 2015-07-23 /pmc/articles/PMC4523144/ /pubmed/26244119 http://dx.doi.org/10.7759/cureus.287 Text en Copyright © 2015, Ramakrishna et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
Ramakrishna, Rohan
Pisapia, David
Recent Molecular Advances in Our Understanding of Glioma
title Recent Molecular Advances in Our Understanding of Glioma
title_full Recent Molecular Advances in Our Understanding of Glioma
title_fullStr Recent Molecular Advances in Our Understanding of Glioma
title_full_unstemmed Recent Molecular Advances in Our Understanding of Glioma
title_short Recent Molecular Advances in Our Understanding of Glioma
title_sort recent molecular advances in our understanding of glioma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523144/
https://www.ncbi.nlm.nih.gov/pubmed/26244119
http://dx.doi.org/10.7759/cureus.287
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