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Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression
BACKGROUND: Previous reports have inferred a linear relationship between LDL-C and changes in coronary plaque volume (CPV) measured by intravascular ultrasound. However, these publications included a small number of studies and did not explore other lipid markers. OBJECTIVE: To assess the associatio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cardiologia
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523283/ https://www.ncbi.nlm.nih.gov/pubmed/26016784 http://dx.doi.org/10.5935/abc.20150050 |
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author | Masson, Walter Siniawski, Daniel Lobo, Martín Molinero, Graciela Giorgi, Mariano Huerín, Melina |
author_facet | Masson, Walter Siniawski, Daniel Lobo, Martín Molinero, Graciela Giorgi, Mariano Huerín, Melina |
author_sort | Masson, Walter |
collection | PubMed |
description | BACKGROUND: Previous reports have inferred a linear relationship between LDL-C and changes in coronary plaque volume (CPV) measured by intravascular ultrasound. However, these publications included a small number of studies and did not explore other lipid markers. OBJECTIVE: To assess the association between changes in lipid markers and regression of CPV using published data. METHODS: We collected data from the control, placebo and intervention arms in studies that compared the effect of lipidlowering treatments on CPV, and from the placebo and control arms in studies that tested drugs that did not affect lipids. Baseline and final measurements of plaque volume, expressed in mm(3), were extracted and the percentage changes after the interventions were calculated. Performing three linear regression analyses, we assessed the relationship between percentage and absolute changes in lipid markers and percentage variations in CPV. RESULTS: Twenty-seven studies were selected. Correlations between percentage changes in LDL-C, non-HDL-C, and apolipoprotein B (ApoB) and percentage changes in CPV were moderate (r = 0.48, r = 0.47, and r = 0.44, respectively). Correlations between absolute differences in LDL-C, non‑HDL-C, and ApoB with percentage differences in CPV were stronger (r = 0.57, r = 0.52, and r = 0.79). The linear regression model showed a statistically significant association between a reduction in lipid markers and regression of plaque volume. CONCLUSION: A significant association between changes in different atherogenic particles and regression of CPV was observed. The absolute reduction in ApoB showed the strongest correlation with coronary plaque regression. |
format | Online Article Text |
id | pubmed-4523283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Sociedade Brasileira de Cardiologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-45232832015-08-07 Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression Masson, Walter Siniawski, Daniel Lobo, Martín Molinero, Graciela Giorgi, Mariano Huerín, Melina Arq Bras Cardiol Original Articles BACKGROUND: Previous reports have inferred a linear relationship between LDL-C and changes in coronary plaque volume (CPV) measured by intravascular ultrasound. However, these publications included a small number of studies and did not explore other lipid markers. OBJECTIVE: To assess the association between changes in lipid markers and regression of CPV using published data. METHODS: We collected data from the control, placebo and intervention arms in studies that compared the effect of lipidlowering treatments on CPV, and from the placebo and control arms in studies that tested drugs that did not affect lipids. Baseline and final measurements of plaque volume, expressed in mm(3), were extracted and the percentage changes after the interventions were calculated. Performing three linear regression analyses, we assessed the relationship between percentage and absolute changes in lipid markers and percentage variations in CPV. RESULTS: Twenty-seven studies were selected. Correlations between percentage changes in LDL-C, non-HDL-C, and apolipoprotein B (ApoB) and percentage changes in CPV were moderate (r = 0.48, r = 0.47, and r = 0.44, respectively). Correlations between absolute differences in LDL-C, non‑HDL-C, and ApoB with percentage differences in CPV were stronger (r = 0.57, r = 0.52, and r = 0.79). The linear regression model showed a statistically significant association between a reduction in lipid markers and regression of plaque volume. CONCLUSION: A significant association between changes in different atherogenic particles and regression of CPV was observed. The absolute reduction in ApoB showed the strongest correlation with coronary plaque regression. Sociedade Brasileira de Cardiologia 2015-07 /pmc/articles/PMC4523283/ /pubmed/26016784 http://dx.doi.org/10.5935/abc.20150050 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License which permits unrestricted noncommercial use, distribution, and reproduction in any medium provided the original work is properly cited. |
spellingShingle | Original Articles Masson, Walter Siniawski, Daniel Lobo, Martín Molinero, Graciela Giorgi, Mariano Huerín, Melina Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with Coronary Plaque Regression |
title | Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with
Coronary Plaque Regression |
title_full | Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with
Coronary Plaque Regression |
title_fullStr | Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with
Coronary Plaque Regression |
title_full_unstemmed | Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with
Coronary Plaque Regression |
title_short | Association between LDL-C, Non HDL-C, and Apolipoprotein B Levels with
Coronary Plaque Regression |
title_sort | association between ldl-c, non hdl-c, and apolipoprotein b levels with
coronary plaque regression |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523283/ https://www.ncbi.nlm.nih.gov/pubmed/26016784 http://dx.doi.org/10.5935/abc.20150050 |
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