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The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT(7) receptors

BACKGROUND AND PURPOSE: Classically, ligands of GPCRs have been classified primarily upon their affinity and efficacy to activate a signal transduction pathway. Recent reports indicate that the efficacy of a particular ligand can vary depending on the receptor-mediated response measured (e.g. activa...

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Detalles Bibliográficos
Autores principales:	Andressen, K W, Manfra, O, Brevik, C H, Ulsund, A H, Vanhoenacker, P, Levy, F O, Krobert, K A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523340/ https://www.ncbi.nlm.nih.gov/pubmed/25884989 http://dx.doi.org/10.1111/bph.13169

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