Cargando…
Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study
Objectives. In some rheumatoid arthritis (RA) patients, joint pain persists without signs of inflammation. This indicates that central pain sensitisation may play a role in the generation of chronic pain in a subgroup of RA. Our aim was to assess the degree of peripheral and central pain sensitisati...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523644/ https://www.ncbi.nlm.nih.gov/pubmed/26266046 http://dx.doi.org/10.1155/2015/434109 |
_version_ | 1782384081077534720 |
---|---|
author | Vladimirova, Nora Jespersen, Anders Bartels, Else Marie Christensen, Anton W. Bliddal, Henning Danneskiold-Samsøe, Bente |
author_facet | Vladimirova, Nora Jespersen, Anders Bartels, Else Marie Christensen, Anton W. Bliddal, Henning Danneskiold-Samsøe, Bente |
author_sort | Vladimirova, Nora |
collection | PubMed |
description | Objectives. In some rheumatoid arthritis (RA) patients, joint pain persists without signs of inflammation. This indicates that central pain sensitisation may play a role in the generation of chronic pain in a subgroup of RA. Our aim was to assess the degree of peripheral and central pain sensitisation in women with active RA compared to healthy controls (HC). Methods. 38 women with active RA (DAS28 > 2.6) and 38 female HC were included in, and completed, the study. Exclusion criteria were polyneuropathy, pregnancy, and no Danish language. Cuff Pressure Algometry measurements were carried out on the dominant lower leg. Pain threshold, pain tolerance, and pain sensitivity during tonic painful stimulation were recorded. Results. Women with active RA had significantly lower pain threshold (p < 0.01) and pain tolerance (p < 0.01) than HC. The mean temporal summation- (TS-) index in RA patients was 0.98 (SEM: 0.09) and 0.71 (SEM: 0.04) in HC (p < 0.01). Conclusion. Patients with active RA showed decreased pressure-pain threshold compared to HC. In addition, temporal summation of pressure-pain was increased, indicating central pain sensitization, at least in some patients. Defining this subgroup of patients may be of importance when considering treatment strategies. |
format | Online Article Text |
id | pubmed-4523644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45236442015-08-11 Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study Vladimirova, Nora Jespersen, Anders Bartels, Else Marie Christensen, Anton W. Bliddal, Henning Danneskiold-Samsøe, Bente Arthritis Research Article Objectives. In some rheumatoid arthritis (RA) patients, joint pain persists without signs of inflammation. This indicates that central pain sensitisation may play a role in the generation of chronic pain in a subgroup of RA. Our aim was to assess the degree of peripheral and central pain sensitisation in women with active RA compared to healthy controls (HC). Methods. 38 women with active RA (DAS28 > 2.6) and 38 female HC were included in, and completed, the study. Exclusion criteria were polyneuropathy, pregnancy, and no Danish language. Cuff Pressure Algometry measurements were carried out on the dominant lower leg. Pain threshold, pain tolerance, and pain sensitivity during tonic painful stimulation were recorded. Results. Women with active RA had significantly lower pain threshold (p < 0.01) and pain tolerance (p < 0.01) than HC. The mean temporal summation- (TS-) index in RA patients was 0.98 (SEM: 0.09) and 0.71 (SEM: 0.04) in HC (p < 0.01). Conclusion. Patients with active RA showed decreased pressure-pain threshold compared to HC. In addition, temporal summation of pressure-pain was increased, indicating central pain sensitization, at least in some patients. Defining this subgroup of patients may be of importance when considering treatment strategies. Hindawi Publishing Corporation 2015 2015-07-21 /pmc/articles/PMC4523644/ /pubmed/26266046 http://dx.doi.org/10.1155/2015/434109 Text en Copyright © 2015 Nora Vladimirova et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Vladimirova, Nora Jespersen, Anders Bartels, Else Marie Christensen, Anton W. Bliddal, Henning Danneskiold-Samsøe, Bente Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study |
title | Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study |
title_full | Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study |
title_fullStr | Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study |
title_full_unstemmed | Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study |
title_short | Pain Sensitisation in Women with Active Rheumatoid Arthritis: A Comparative Cross-Sectional Study |
title_sort | pain sensitisation in women with active rheumatoid arthritis: a comparative cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523644/ https://www.ncbi.nlm.nih.gov/pubmed/26266046 http://dx.doi.org/10.1155/2015/434109 |
work_keys_str_mv | AT vladimirovanora painsensitisationinwomenwithactiverheumatoidarthritisacomparativecrosssectionalstudy AT jespersenanders painsensitisationinwomenwithactiverheumatoidarthritisacomparativecrosssectionalstudy AT bartelselsemarie painsensitisationinwomenwithactiverheumatoidarthritisacomparativecrosssectionalstudy AT christensenantonw painsensitisationinwomenwithactiverheumatoidarthritisacomparativecrosssectionalstudy AT bliddalhenning painsensitisationinwomenwithactiverheumatoidarthritisacomparativecrosssectionalstudy AT danneskioldsamsøebente painsensitisationinwomenwithactiverheumatoidarthritisacomparativecrosssectionalstudy |