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Surgical and Pathological Changes after Radiofrequency Ablation of Thyroid Nodules

Background. Radiofrequency ablation (RFA) has been recently advocated as an effective technique for the treatment of symptomatic benign thyroid nodules. It is not known to what extent it may affect any subsequent thyroid surgery and/or histological diagnosis. Materials and Methods. RFA was performed...

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Autores principales: Dobrinja, Chiara, Bernardi, Stella, Fabris, Bruno, Eramo, Rita, Makovac, Petra, Bazzocchi, Gabriele, Piscopello, Lanfranco, Barro, Enrica, de Manzini, Nicolò, Bonazza, Deborah, Pinamonti, Maurizio, Zanconati, Fabrizio, Stacul, Fulvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523654/
https://www.ncbi.nlm.nih.gov/pubmed/26265914
http://dx.doi.org/10.1155/2015/576576
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author Dobrinja, Chiara
Bernardi, Stella
Fabris, Bruno
Eramo, Rita
Makovac, Petra
Bazzocchi, Gabriele
Piscopello, Lanfranco
Barro, Enrica
de Manzini, Nicolò
Bonazza, Deborah
Pinamonti, Maurizio
Zanconati, Fabrizio
Stacul, Fulvio
author_facet Dobrinja, Chiara
Bernardi, Stella
Fabris, Bruno
Eramo, Rita
Makovac, Petra
Bazzocchi, Gabriele
Piscopello, Lanfranco
Barro, Enrica
de Manzini, Nicolò
Bonazza, Deborah
Pinamonti, Maurizio
Zanconati, Fabrizio
Stacul, Fulvio
author_sort Dobrinja, Chiara
collection PubMed
description Background. Radiofrequency ablation (RFA) has been recently advocated as an effective technique for the treatment of symptomatic benign thyroid nodules. It is not known to what extent it may affect any subsequent thyroid surgery and/or histological diagnosis. Materials and Methods. RFA was performed on 64 symptomatic Thy2 nodules (benign nodules) and 6 symptomatic Thy3 nodules (follicular lesions/follicular neoplasms). Two Thy3 nodules regrew after the procedure, and these patients accepted to undergo a total thyroidectomy. Here we present how RFA has affected the operation and the final pathological features of the surgically removed nodules. Results and Conclusions. RFA is effective for the treatment of Thy2 nodules, but it should not be recommended as first-line therapy for the treatment of Thy3 nodules (irrespective of their mutational status), as it delays surgery in case of malignancy. Moreover, it is unknown whether RFA might promote residual tumor progression or neoplastic progression of Thy3 lesions. Nevertheless, here we show for the first time that one session of RFA does not affect subsequent thyroid surgery and/or histological diagnosis.
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spelling pubmed-45236542015-08-11 Surgical and Pathological Changes after Radiofrequency Ablation of Thyroid Nodules Dobrinja, Chiara Bernardi, Stella Fabris, Bruno Eramo, Rita Makovac, Petra Bazzocchi, Gabriele Piscopello, Lanfranco Barro, Enrica de Manzini, Nicolò Bonazza, Deborah Pinamonti, Maurizio Zanconati, Fabrizio Stacul, Fulvio Int J Endocrinol Research Article Background. Radiofrequency ablation (RFA) has been recently advocated as an effective technique for the treatment of symptomatic benign thyroid nodules. It is not known to what extent it may affect any subsequent thyroid surgery and/or histological diagnosis. Materials and Methods. RFA was performed on 64 symptomatic Thy2 nodules (benign nodules) and 6 symptomatic Thy3 nodules (follicular lesions/follicular neoplasms). Two Thy3 nodules regrew after the procedure, and these patients accepted to undergo a total thyroidectomy. Here we present how RFA has affected the operation and the final pathological features of the surgically removed nodules. Results and Conclusions. RFA is effective for the treatment of Thy2 nodules, but it should not be recommended as first-line therapy for the treatment of Thy3 nodules (irrespective of their mutational status), as it delays surgery in case of malignancy. Moreover, it is unknown whether RFA might promote residual tumor progression or neoplastic progression of Thy3 lesions. Nevertheless, here we show for the first time that one session of RFA does not affect subsequent thyroid surgery and/or histological diagnosis. Hindawi Publishing Corporation 2015 2015-07-21 /pmc/articles/PMC4523654/ /pubmed/26265914 http://dx.doi.org/10.1155/2015/576576 Text en Copyright © 2015 Chiara Dobrinja et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dobrinja, Chiara
Bernardi, Stella
Fabris, Bruno
Eramo, Rita
Makovac, Petra
Bazzocchi, Gabriele
Piscopello, Lanfranco
Barro, Enrica
de Manzini, Nicolò
Bonazza, Deborah
Pinamonti, Maurizio
Zanconati, Fabrizio
Stacul, Fulvio
Surgical and Pathological Changes after Radiofrequency Ablation of Thyroid Nodules
title Surgical and Pathological Changes after Radiofrequency Ablation of Thyroid Nodules
title_full Surgical and Pathological Changes after Radiofrequency Ablation of Thyroid Nodules
title_fullStr Surgical and Pathological Changes after Radiofrequency Ablation of Thyroid Nodules
title_full_unstemmed Surgical and Pathological Changes after Radiofrequency Ablation of Thyroid Nodules
title_short Surgical and Pathological Changes after Radiofrequency Ablation of Thyroid Nodules
title_sort surgical and pathological changes after radiofrequency ablation of thyroid nodules
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523654/
https://www.ncbi.nlm.nih.gov/pubmed/26265914
http://dx.doi.org/10.1155/2015/576576
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