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Daily Oxygen/O(3) Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise

Rats receiving daily intraperitoneal administration of O(2) and running on a treadmill covered an average distance of 482.8 ± 21.8 m/week as calculated during 5-week observation. This distance was increased in rats receiving daily intraperitoneal administration of an oxygen/O(3) mixture at a dose of...

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Autores principales: Di Filippo, C., Trotta, M. C., Maisto, R., Siniscalco, D., Luongo, M., Mascolo, L., Alfano, R., Accardo, M., Rossi, C., Ferraraccio, F., D'Amico, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523667/
https://www.ncbi.nlm.nih.gov/pubmed/26265981
http://dx.doi.org/10.1155/2015/190640
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author Di Filippo, C.
Trotta, M. C.
Maisto, R.
Siniscalco, D.
Luongo, M.
Mascolo, L.
Alfano, R.
Accardo, M.
Rossi, C.
Ferraraccio, F.
D'Amico, M.
author_facet Di Filippo, C.
Trotta, M. C.
Maisto, R.
Siniscalco, D.
Luongo, M.
Mascolo, L.
Alfano, R.
Accardo, M.
Rossi, C.
Ferraraccio, F.
D'Amico, M.
author_sort Di Filippo, C.
collection PubMed
description Rats receiving daily intraperitoneal administration of O(2) and running on a treadmill covered an average distance of 482.8 ± 21.8 m/week as calculated during 5-week observation. This distance was increased in rats receiving daily intraperitoneal administration of an oxygen/O(3) mixture at a dose of 100; 150; and 300 μg/kg with the maximum increase being +34.5% at 300 μg/kg and still present after stopping the administration of oxygen/O(3). Oxygen/O(3) decreased the mean arterial blood pressure (−13%), the heart rate (−6%), the gastrocnemius and cardiac hypertrophy, and fibrosis and reduced by 49% the left ventricular mass and relative wall thickness measurements. Systolic and diastolic functions were improved in exercised oxygen/O(3) rats compared to O(2) rats. Oxygen/O(3) treatment led to higher MPI index starting from the dose of 150 μg/kg (p < 0.05) and more effective (+14%) at a dose of 300 μg/kg oxygen/O(3). Oxygen/O(3) dose-dependently increased the expression of the antioxidant enzymes Mn-SOD and GPx1 and of eNOS compared to the exercised O(2) rats. The same doses resulted in decrease of LDH levels, CPK, TnI, and nitrotyrosine concentration in the heart and gastrocnemius tissues, arguing a beneficial effect of the ozone molecule against the fatigue induced by a prolonged high intensity exercise.
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spelling pubmed-45236672015-08-11 Daily Oxygen/O(3) Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise Di Filippo, C. Trotta, M. C. Maisto, R. Siniscalco, D. Luongo, M. Mascolo, L. Alfano, R. Accardo, M. Rossi, C. Ferraraccio, F. D'Amico, M. Oxid Med Cell Longev Research Article Rats receiving daily intraperitoneal administration of O(2) and running on a treadmill covered an average distance of 482.8 ± 21.8 m/week as calculated during 5-week observation. This distance was increased in rats receiving daily intraperitoneal administration of an oxygen/O(3) mixture at a dose of 100; 150; and 300 μg/kg with the maximum increase being +34.5% at 300 μg/kg and still present after stopping the administration of oxygen/O(3). Oxygen/O(3) decreased the mean arterial blood pressure (−13%), the heart rate (−6%), the gastrocnemius and cardiac hypertrophy, and fibrosis and reduced by 49% the left ventricular mass and relative wall thickness measurements. Systolic and diastolic functions were improved in exercised oxygen/O(3) rats compared to O(2) rats. Oxygen/O(3) treatment led to higher MPI index starting from the dose of 150 μg/kg (p < 0.05) and more effective (+14%) at a dose of 300 μg/kg oxygen/O(3). Oxygen/O(3) dose-dependently increased the expression of the antioxidant enzymes Mn-SOD and GPx1 and of eNOS compared to the exercised O(2) rats. The same doses resulted in decrease of LDH levels, CPK, TnI, and nitrotyrosine concentration in the heart and gastrocnemius tissues, arguing a beneficial effect of the ozone molecule against the fatigue induced by a prolonged high intensity exercise. Hindawi Publishing Corporation 2015 2015-07-21 /pmc/articles/PMC4523667/ /pubmed/26265981 http://dx.doi.org/10.1155/2015/190640 Text en Copyright © 2015 C. Di Filippo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Di Filippo, C.
Trotta, M. C.
Maisto, R.
Siniscalco, D.
Luongo, M.
Mascolo, L.
Alfano, R.
Accardo, M.
Rossi, C.
Ferraraccio, F.
D'Amico, M.
Daily Oxygen/O(3) Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise
title Daily Oxygen/O(3) Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise
title_full Daily Oxygen/O(3) Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise
title_fullStr Daily Oxygen/O(3) Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise
title_full_unstemmed Daily Oxygen/O(3) Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise
title_short Daily Oxygen/O(3) Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise
title_sort daily oxygen/o(3) treatment reduces muscular fatigue and improves cardiac performance in rats subjected to prolonged high intensity physical exercise
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523667/
https://www.ncbi.nlm.nih.gov/pubmed/26265981
http://dx.doi.org/10.1155/2015/190640
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