USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms

Nuclear factor κB (NF-κB) is a key transcription factor in inflammatory immune responses and cell survival. Multiple types of ubiquitination play critical roles in the activation of NF-κB signaling, yet the molecular mechanisms responsible for their reversible deubiquitination are still poorly under...

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Detalles Bibliográficos
Autores principales: Yang, Zhifen, Xian, Huifang, Hu, Jiajia, Tian, Shuo, Qin, Yunfei, Wang, Rong-Fu, Cui, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523862/
https://www.ncbi.nlm.nih.gov/pubmed/26240016
http://dx.doi.org/10.1038/srep12738

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