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Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach
A robust and convenient research strategy integrating state-of-the-art analytical techniques is needed to efficiently discover novel compounds from marine microbial resources. In this study, we identified a series of amino-polyketide derivatives, vitroprocines A-J, from the marine bacterium Vibrio s...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523872/ https://www.ncbi.nlm.nih.gov/pubmed/26238555 http://dx.doi.org/10.1038/srep12856 |
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author | Liaw, Chih-Chuang Chen, Pei-Chin Shih, Chao-Jen Tseng, Sung-Pin Lai, Ying-Mi Hsu, Chi-Hsin Dorrestein, Pieter C. Yang, Yu-Liang |
author_facet | Liaw, Chih-Chuang Chen, Pei-Chin Shih, Chao-Jen Tseng, Sung-Pin Lai, Ying-Mi Hsu, Chi-Hsin Dorrestein, Pieter C. Yang, Yu-Liang |
author_sort | Liaw, Chih-Chuang |
collection | PubMed |
description | A robust and convenient research strategy integrating state-of-the-art analytical techniques is needed to efficiently discover novel compounds from marine microbial resources. In this study, we identified a series of amino-polyketide derivatives, vitroprocines A-J, from the marine bacterium Vibrio sp. QWI-06 by an integrated approach using imaging mass spectroscopy and molecular networking, as well as conventional bioactivity-guided fractionation and isolation. The structure-activity relationship of vitroprocines against Acinetobacter baumannii is proposed. In addition, feeding experiments with (13)C-labeled precursors indicated that a pyridoxal 5′-phosphate-dependent mechanism is involved in the biosynthesis of vitroprocines. Elucidation of amino-polyketide derivatives from a species of marine bacteria for the first time demonstrates the potential of this integrated metabolomics approach to uncover marine bacterial biodiversity. |
format | Online Article Text |
id | pubmed-4523872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45238722015-08-05 Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach Liaw, Chih-Chuang Chen, Pei-Chin Shih, Chao-Jen Tseng, Sung-Pin Lai, Ying-Mi Hsu, Chi-Hsin Dorrestein, Pieter C. Yang, Yu-Liang Sci Rep Article A robust and convenient research strategy integrating state-of-the-art analytical techniques is needed to efficiently discover novel compounds from marine microbial resources. In this study, we identified a series of amino-polyketide derivatives, vitroprocines A-J, from the marine bacterium Vibrio sp. QWI-06 by an integrated approach using imaging mass spectroscopy and molecular networking, as well as conventional bioactivity-guided fractionation and isolation. The structure-activity relationship of vitroprocines against Acinetobacter baumannii is proposed. In addition, feeding experiments with (13)C-labeled precursors indicated that a pyridoxal 5′-phosphate-dependent mechanism is involved in the biosynthesis of vitroprocines. Elucidation of amino-polyketide derivatives from a species of marine bacteria for the first time demonstrates the potential of this integrated metabolomics approach to uncover marine bacterial biodiversity. Nature Publishing Group 2015-08-04 /pmc/articles/PMC4523872/ /pubmed/26238555 http://dx.doi.org/10.1038/srep12856 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liaw, Chih-Chuang Chen, Pei-Chin Shih, Chao-Jen Tseng, Sung-Pin Lai, Ying-Mi Hsu, Chi-Hsin Dorrestein, Pieter C. Yang, Yu-Liang Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach |
title | Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach |
title_full | Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach |
title_fullStr | Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach |
title_full_unstemmed | Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach |
title_short | Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach |
title_sort | vitroprocines, new antibiotics against acinetobacter baumannii, discovered from marine vibrio sp. qwi-06 using mass-spectrometry-based metabolomics approach |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523872/ https://www.ncbi.nlm.nih.gov/pubmed/26238555 http://dx.doi.org/10.1038/srep12856 |
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