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Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans
INTRODUCTION: Ibuprofen is one of the nonsteroidal anti-inflammatory drugs that have been shown to selectively lower pathogenic amyloid beta-peptide (Aβ)42 without impairing overall γ-secretase activity in vitro. This γ-secretase modulator (GSM) activity has been hypothesized to contribute to the re...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523931/ https://www.ncbi.nlm.nih.gov/pubmed/26244059 http://dx.doi.org/10.1186/s13195-015-0137-y |