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Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans

INTRODUCTION: Ibuprofen is one of the nonsteroidal anti-inflammatory drugs that have been shown to selectively lower pathogenic amyloid beta-peptide (Aβ)42 without impairing overall γ-secretase activity in vitro. This γ-secretase modulator (GSM) activity has been hypothesized to contribute to the re...

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Detalles Bibliográficos
Autores principales:	Ling, I-Fang, Golde, Todd E., Galasko, Douglas R., Koo, Edward H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523931/ https://www.ncbi.nlm.nih.gov/pubmed/26244059 http://dx.doi.org/10.1186/s13195-015-0137-y

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