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Two cases of hard metal lung disease showing gradual improvement in pulmonary function after avoiding dust exposure

We present herein two cases of hard metal lung disease (HMLD) with distinct pathological findings. Both cases showed gradual improvements in pulmonary function over a period of a few years (Case 1: 30 months; Case 2: 12 months) after the avoidance of dust exposure, while improvements on high-resolut...

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Autores principales: Terui, Hiroya, Konno, Satoshi, Kaga, Kichizo, Matsuno, Yoshihiro, Hatanaka, Kanako C., Kanno, Hiromi, Moriyama, Hiroshi, Uo, Motohiro, Nishimura, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524026/
https://www.ncbi.nlm.nih.gov/pubmed/26244050
http://dx.doi.org/10.1186/s12995-015-0070-9
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author Terui, Hiroya
Konno, Satoshi
Kaga, Kichizo
Matsuno, Yoshihiro
Hatanaka, Kanako C.
Kanno, Hiromi
Moriyama, Hiroshi
Uo, Motohiro
Nishimura, Masaharu
author_facet Terui, Hiroya
Konno, Satoshi
Kaga, Kichizo
Matsuno, Yoshihiro
Hatanaka, Kanako C.
Kanno, Hiromi
Moriyama, Hiroshi
Uo, Motohiro
Nishimura, Masaharu
author_sort Terui, Hiroya
collection PubMed
description We present herein two cases of hard metal lung disease (HMLD) with distinct pathological findings. Both cases showed gradual improvements in pulmonary function over a period of a few years (Case 1: 30 months; Case 2: 12 months) after the avoidance of dust exposure, while improvements on high-resolution computed tomography were modest. The increased lymphocytes and decreased CD4/CD8 ratio in BALF observed at initial diagnosis normalized after the avoidance of dust exposure in one case. To the best of our knowledge, this is the first report demonstrating continual follow-up of pulmonary function and radiographic findings, and a comparison of BALF findings before and after avoidance of hard metal dust exposure.
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spelling pubmed-45240262015-08-05 Two cases of hard metal lung disease showing gradual improvement in pulmonary function after avoiding dust exposure Terui, Hiroya Konno, Satoshi Kaga, Kichizo Matsuno, Yoshihiro Hatanaka, Kanako C. Kanno, Hiromi Moriyama, Hiroshi Uo, Motohiro Nishimura, Masaharu J Occup Med Toxicol Case Report We present herein two cases of hard metal lung disease (HMLD) with distinct pathological findings. Both cases showed gradual improvements in pulmonary function over a period of a few years (Case 1: 30 months; Case 2: 12 months) after the avoidance of dust exposure, while improvements on high-resolution computed tomography were modest. The increased lymphocytes and decreased CD4/CD8 ratio in BALF observed at initial diagnosis normalized after the avoidance of dust exposure in one case. To the best of our knowledge, this is the first report demonstrating continual follow-up of pulmonary function and radiographic findings, and a comparison of BALF findings before and after avoidance of hard metal dust exposure. BioMed Central 2015-08-04 /pmc/articles/PMC4524026/ /pubmed/26244050 http://dx.doi.org/10.1186/s12995-015-0070-9 Text en © Terui et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Terui, Hiroya
Konno, Satoshi
Kaga, Kichizo
Matsuno, Yoshihiro
Hatanaka, Kanako C.
Kanno, Hiromi
Moriyama, Hiroshi
Uo, Motohiro
Nishimura, Masaharu
Two cases of hard metal lung disease showing gradual improvement in pulmonary function after avoiding dust exposure
title Two cases of hard metal lung disease showing gradual improvement in pulmonary function after avoiding dust exposure
title_full Two cases of hard metal lung disease showing gradual improvement in pulmonary function after avoiding dust exposure
title_fullStr Two cases of hard metal lung disease showing gradual improvement in pulmonary function after avoiding dust exposure
title_full_unstemmed Two cases of hard metal lung disease showing gradual improvement in pulmonary function after avoiding dust exposure
title_short Two cases of hard metal lung disease showing gradual improvement in pulmonary function after avoiding dust exposure
title_sort two cases of hard metal lung disease showing gradual improvement in pulmonary function after avoiding dust exposure
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524026/
https://www.ncbi.nlm.nih.gov/pubmed/26244050
http://dx.doi.org/10.1186/s12995-015-0070-9
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