A novel placental like alkaline phosphate promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting

BACKGROUND: Placental like alkaline phosphate (PLAP), an oncofetal antigen, is highly expressed in germ cell, cervical, ovarian and several other tumour types but minimally in normal tissues. The expression of a PLAP promoter based transcriptional unit following antigen mediated cell specific delive...

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Detalles Bibliográficos
Autores principales: Khan, Imran, Zakaria, Mohammad Khalid, Kumar, Mukesh, Mani, Prashant, Chattopadhyay, Parthaprasad, Sarkar, Debi P, Sinha, Subrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524171/
https://www.ncbi.nlm.nih.gov/pubmed/26242403
http://dx.doi.org/10.1186/s12967-015-0602-1

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