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Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro

BACKGROUND: Autophagy is a conserved cellular self-digestion mechanism that can either suppress or promote cancer in a context-dependent manner. In ovarian cancer, prevalent mono-allelic deletion of BECN1 (a canonical autophagy-inducer) suggests that autophagy is impaired to promote carcinogenesis a...

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Detalles Bibliográficos
Autores principales:	Correa, Rohann J. M., Valdes, Yudith Ramos, Shepherd, Trevor G., DiMattia, Gabriel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524172/ https://www.ncbi.nlm.nih.gov/pubmed/26239434 http://dx.doi.org/10.1186/s13048-015-0182-y

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