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Adolescent idiopathic scoliosis without limb weakness: a differential diagnosis of core myopathy?
BACKGROUND: Core myopathies are a clinically and genetically heterogeneous group of congenital myopathies with the common defined histopathological feature of focally reduced oxidative activity on muscle biopsy. It has a low incidence, however, recent articles show broad clinical spectrum, suggestin...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524392/ https://www.ncbi.nlm.nih.gov/pubmed/26242231 http://dx.doi.org/10.1186/s12891-015-0629-8 |
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author | Luciano, Rafael de Paiva Puertas, Eduardo Barros Martins, Delio Eulalio Faloppa, Flavio Del Curto, David Rodrigues, Luciano Miller Reis Schmidt, Beny de Oliveira, Acary Souza Bulle Wajchenberg, Marcelo |
author_facet | Luciano, Rafael de Paiva Puertas, Eduardo Barros Martins, Delio Eulalio Faloppa, Flavio Del Curto, David Rodrigues, Luciano Miller Reis Schmidt, Beny de Oliveira, Acary Souza Bulle Wajchenberg, Marcelo |
author_sort | Luciano, Rafael de Paiva |
collection | PubMed |
description | BACKGROUND: Core myopathies are a clinically and genetically heterogeneous group of congenital myopathies with the common defined histopathological feature of focally reduced oxidative activity on muscle biopsy. It has a low incidence, however, recent articles show broad clinical spectrum, suggesting that the real incidence should be considerably larger than previously described. Due to the important association between scoliosis and paravertebral muscle imbalance, numerous authors study, by biopsy of the spinal rotator muscles, potential changes that may elucidate the etiology of adolescent idiopathic scoliosis. CASE PRESENTATION: Two patients have been followed at Spine Group of Department of Orthopedics at Federal University of São Paulo, with an initial diagnosis of idiopathic scoliosis. Both patients had clinical and radiological findings compatible with it. The patients authorized, through the Term of Consent, intraoperative biopsy of muscle multifidus from the apex of the thoracic curve on concave and convex sides. After muscle biopsy was performed a histopathological analysis. As regard to the histopathological features: in both patients were identified, the presence of core structures in extensive areas with reduced oxidative activity running along the muscle fiber. CONCLUSIONS: All patients with ‘idiopathic’ scoliosis deserve a careful neurological evaluation, even if they have minimal muscle symptoms in the extremities. The frequent occurrence of scoliosis in patients with CORE Myopathies, supports the thesis that the change in the paravertebral muscle fiber must be the underlying pathogenic factor in scoliosis and may help us understand the onset and progression of curves in patients previously diagnosed with idiopathic scoliosis. |
format | Online Article Text |
id | pubmed-4524392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45243922015-08-05 Adolescent idiopathic scoliosis without limb weakness: a differential diagnosis of core myopathy? Luciano, Rafael de Paiva Puertas, Eduardo Barros Martins, Delio Eulalio Faloppa, Flavio Del Curto, David Rodrigues, Luciano Miller Reis Schmidt, Beny de Oliveira, Acary Souza Bulle Wajchenberg, Marcelo BMC Musculoskelet Disord Case Report BACKGROUND: Core myopathies are a clinically and genetically heterogeneous group of congenital myopathies with the common defined histopathological feature of focally reduced oxidative activity on muscle biopsy. It has a low incidence, however, recent articles show broad clinical spectrum, suggesting that the real incidence should be considerably larger than previously described. Due to the important association between scoliosis and paravertebral muscle imbalance, numerous authors study, by biopsy of the spinal rotator muscles, potential changes that may elucidate the etiology of adolescent idiopathic scoliosis. CASE PRESENTATION: Two patients have been followed at Spine Group of Department of Orthopedics at Federal University of São Paulo, with an initial diagnosis of idiopathic scoliosis. Both patients had clinical and radiological findings compatible with it. The patients authorized, through the Term of Consent, intraoperative biopsy of muscle multifidus from the apex of the thoracic curve on concave and convex sides. After muscle biopsy was performed a histopathological analysis. As regard to the histopathological features: in both patients were identified, the presence of core structures in extensive areas with reduced oxidative activity running along the muscle fiber. CONCLUSIONS: All patients with ‘idiopathic’ scoliosis deserve a careful neurological evaluation, even if they have minimal muscle symptoms in the extremities. The frequent occurrence of scoliosis in patients with CORE Myopathies, supports the thesis that the change in the paravertebral muscle fiber must be the underlying pathogenic factor in scoliosis and may help us understand the onset and progression of curves in patients previously diagnosed with idiopathic scoliosis. BioMed Central 2015-08-05 /pmc/articles/PMC4524392/ /pubmed/26242231 http://dx.doi.org/10.1186/s12891-015-0629-8 Text en © Luciano et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Luciano, Rafael de Paiva Puertas, Eduardo Barros Martins, Delio Eulalio Faloppa, Flavio Del Curto, David Rodrigues, Luciano Miller Reis Schmidt, Beny de Oliveira, Acary Souza Bulle Wajchenberg, Marcelo Adolescent idiopathic scoliosis without limb weakness: a differential diagnosis of core myopathy? |
title | Adolescent idiopathic scoliosis without limb weakness: a differential diagnosis of core myopathy? |
title_full | Adolescent idiopathic scoliosis without limb weakness: a differential diagnosis of core myopathy? |
title_fullStr | Adolescent idiopathic scoliosis without limb weakness: a differential diagnosis of core myopathy? |
title_full_unstemmed | Adolescent idiopathic scoliosis without limb weakness: a differential diagnosis of core myopathy? |
title_short | Adolescent idiopathic scoliosis without limb weakness: a differential diagnosis of core myopathy? |
title_sort | adolescent idiopathic scoliosis without limb weakness: a differential diagnosis of core myopathy? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524392/ https://www.ncbi.nlm.nih.gov/pubmed/26242231 http://dx.doi.org/10.1186/s12891-015-0629-8 |
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