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Dynamics of preventive vs post-diagnostic cancer control using low-impact measures

Cancer poses danger because of its unregulated growth, development of resistance, and metastatic spread to vital organs. We currently lack quantitative theory for how preventive measures and post-diagnostic interventions are predicted to affect risks of a life threatening cancer. Here we evaluate ho...

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Detalles Bibliográficos
Autores principales: Akhmetzhanov, Andrei R, Hochberg, Michael E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524440/
https://www.ncbi.nlm.nih.gov/pubmed/26111339
http://dx.doi.org/10.7554/eLife.06266
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author Akhmetzhanov, Andrei R
Hochberg, Michael E
author_facet Akhmetzhanov, Andrei R
Hochberg, Michael E
author_sort Akhmetzhanov, Andrei R
collection PubMed
description Cancer poses danger because of its unregulated growth, development of resistance, and metastatic spread to vital organs. We currently lack quantitative theory for how preventive measures and post-diagnostic interventions are predicted to affect risks of a life threatening cancer. Here we evaluate how continuous measures, such as life style changes and traditional treatments, affect both neoplastic growth and the frequency of resistant clones. We then compare and contrast preventive and post-diagnostic interventions assuming that only a single lesion progresses to invasive carcinoma during the life of an individual, and resection either leaves residual cells or metastases are undetected. Whereas prevention generally results in more positive therapeutic outcomes than post-diagnostic interventions, this advantage is substantially lowered should prevention initially fail to arrest tumour growth. We discuss these results and other important mitigating factors that should be taken into consideration in a comparative understanding of preventive and post-diagnostic interventions. DOI: http://dx.doi.org/10.7554/eLife.06266.001
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spelling pubmed-45244402015-08-05 Dynamics of preventive vs post-diagnostic cancer control using low-impact measures Akhmetzhanov, Andrei R Hochberg, Michael E eLife Computational and Systems Biology Cancer poses danger because of its unregulated growth, development of resistance, and metastatic spread to vital organs. We currently lack quantitative theory for how preventive measures and post-diagnostic interventions are predicted to affect risks of a life threatening cancer. Here we evaluate how continuous measures, such as life style changes and traditional treatments, affect both neoplastic growth and the frequency of resistant clones. We then compare and contrast preventive and post-diagnostic interventions assuming that only a single lesion progresses to invasive carcinoma during the life of an individual, and resection either leaves residual cells or metastases are undetected. Whereas prevention generally results in more positive therapeutic outcomes than post-diagnostic interventions, this advantage is substantially lowered should prevention initially fail to arrest tumour growth. We discuss these results and other important mitigating factors that should be taken into consideration in a comparative understanding of preventive and post-diagnostic interventions. DOI: http://dx.doi.org/10.7554/eLife.06266.001 eLife Sciences Publications, Ltd 2015-06-25 /pmc/articles/PMC4524440/ /pubmed/26111339 http://dx.doi.org/10.7554/eLife.06266 Text en © 2015, Akhmetzhanov and Hochberg http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Computational and Systems Biology
Akhmetzhanov, Andrei R
Hochberg, Michael E
Dynamics of preventive vs post-diagnostic cancer control using low-impact measures
title Dynamics of preventive vs post-diagnostic cancer control using low-impact measures
title_full Dynamics of preventive vs post-diagnostic cancer control using low-impact measures
title_fullStr Dynamics of preventive vs post-diagnostic cancer control using low-impact measures
title_full_unstemmed Dynamics of preventive vs post-diagnostic cancer control using low-impact measures
title_short Dynamics of preventive vs post-diagnostic cancer control using low-impact measures
title_sort dynamics of preventive vs post-diagnostic cancer control using low-impact measures
topic Computational and Systems Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524440/
https://www.ncbi.nlm.nih.gov/pubmed/26111339
http://dx.doi.org/10.7554/eLife.06266
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