Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis

BACKGROUND: The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of the target cell. We have shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in the mouse and that human metastatic melanomas had reduced AhR levels...

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Detalles Bibliográficos
Autores principales: Contador-Troca, María, Alvarez-Barrientos, Alberto, Merino, Jaime M., Morales-Hernández, Antonio, Rodríguez, María I., Rey-Barroso, Javier, Barrasa, Eva, Cerezo-Guisado, María I., Catalina-Fernández, Inmaculada, Sáenz-Santamaría, Javier, Oliver, Francisco J., Fernandez-Salguero, Pedro M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524442/
https://www.ncbi.nlm.nih.gov/pubmed/26242870
http://dx.doi.org/10.1186/s12943-015-0419-9

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